RNF111 - ring finger protein 111 Gene

Also Known as ARK; hRNF111

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54778

About RNF111

Cytogenetic location: 15q22.1-q22.2 Genomic coordinates (GRCh38): 15:58,987,663-59,097,419 (from NCBI)

This gene has 12 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 5.8), brain (RPKM 5.5) and 25 other tissues.

Summary

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin Ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

RNF111 Products (5)

mRNA Protein Name
NM_001270528.2 NP_001257457.1 E3 ubiquitin-protein ligase Arkadia isoform 1
NM_001270529.2 NP_001257458.1 E3 ubiquitin-protein ligase Arkadia isoform 3
NM_001270530.2 NP_001257459.1 E3 ubiquitin-protein ligase Arkadia isoform 4
NM_001330331.2 NP_001317260.1 E3 ubiquitin-protein ligase Arkadia isoform 5
NM_017610.8 NP_060080.6 E3 ubiquitin-protein ligase Arkadia isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables SUMO polymer binding IDA
IDA: Inferred from direct assay
23086935 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16601693 GOA
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
16601693 GOA
Biological Process GO Annotation Evidence References Source
involved in protein ubiquitination IMP
IMP: Inferred from mutant phenotype
16601693 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF111 Protein Structure

RNF111_N

RNF111_N: E3 ubiquitin-protein ligase Arkadia N-terminus (18 - 292)

zf-RING_2

zf-RING_2: Ring finger domain (941 - 983)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 994 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase Arkadia

  • Arkadia

RNF111 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RNF111 Q6ZNA4 b2r8y4_human Homo sapiens B2R8Y4
Validated Y2H
25416956
Intra
RNF111 Q6ZNA4 b2r8y4_human Homo sapiens B2R8Y4
Y2H Prey Pooling
25416956
Intra
RNF111 Q6ZNA4 b2r8y4_human Homo sapiens B2R8Y4
Y2H Array
25416956
Intra
RNF111 Q6ZNA4 EDARADD Homo sapiens Q8WWZ3
Y2H Prey Pooling
25416956
Intra
RNF111 Q6ZNA4 CSNK2A1 Homo sapiens P68400
Anti Tag CoIP
33961781
Intra
RNF111 Q6ZNA4 CSNK2A1 Homo sapiens P68400
Y2H
21516116
Intra
RNF111 Q6ZNA4 CSNK2A1 Homo sapiens P68400
Y2H Array
25416956
Intra
RNF111 Q6ZNA4 CSNK2A1 Homo sapiens P68400
Y2H Array
29892012
Intra
RNF111 Q6ZNA4 UBE2D3 Homo sapiens P61077
Y2H Array
25416956
Intra
RNF111 Q6ZNA4 UBE2D3 Homo sapiens P61077
Y2H Array
19549727
Intra
RNF111 Q6ZNA4 UBE2D3 Homo sapiens P61077
Y2H Prey Pooling
25416956
Intra
RNF111 Q6ZNA4 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra
RNF111 Q6ZNA4 KRTAP5-9 Homo sapiens P26371
Y2H Array
31515488
Intra
RNF111 Q6ZNA4 AXIN1 Homo sapiens O15169
Anti Bait CoIP
16601693
Intra
RNF111 Q6ZNA4 UBE2D1 Homo sapiens P51668
Y2H Array
19690564
Intra
RNF111 Q6ZNA4 UBE2D1 Homo sapiens P51668
Validated Y2H
25416956
Intra
RNF111 Q6ZNA4 UBE2I Homo sapiens P63279
Y2H Array
25416956
Intra
RNF111 Q6ZNA4 UBE2I Homo sapiens P63279
Y2H Pooling
20936779
Intra
RNF111 Q6ZNA4 UBE2I Homo sapiens P63279
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Xeroderma Pigmentosum, Variant Type

  • Xeroderma Pigmentosum

  • XPV

  • Xeroderma Pigmentosum Variant Type

  • Xeroderma Pigmentosum With Normal Dna Repair Rates

  • Photosensitivity With Defective Dna Synthesis

  • Xp

  • De Sanctis-Cacchione Syndrome

  • Desanctis-Cacchione Syndrome

  • Xeroderma Pigmentosa

  • Xerodermic Idiocy

  • Xeroderma Pigmentosum Variant

  • Xp - [Xeroderma Pigmentosum]

  • Atrophoderma Pigmentosum
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12036 RNF111 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RNF111 RGD RGD:1310097
Macaca mulatta RNF111 VGNC VGNC:76751
Mus musculus RNF111 MGD MGI:1934919
Canis familiaris RNF111 VGNC VGNC:45621
Felis catus RNF111 VGNC VGNC:64663
Bos taurus RNF111 VGNC VGNC:34010
Others RNF111 NCBI