ZNF451 - zinc finger protein 451 Gene

Also Known as ZATT; COASTER; dJ417I1.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26036

About ZNF451

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:57,090,188-57,170,305 (from NCBI)

This gene has 18 transcripts (splice variants), 131 orthologues and 36 paralogues. Ubiquitous expression in bone marrow (RPKM 8.1), testis (RPKM 5.2) and 24 other tissues.

Summary

Enables SUMO Ligase activity and transcription corepressor activity. Involved in negative regulation of nitrogen compound metabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF451 Products (3)

mRNA Protein Name
NM_001031623.3 NP_001026794.1 E3 SUMO-protein ligase ZNF451 isoform 1
NM_001257273.2 NP_001244202.1 E3 SUMO-protein ligase ZNF451 isoform 3
NM_015555.3 NP_056370.2 E3 SUMO-protein ligase ZNF451 isoform 2

ZNF451 Protein Structure

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (253 - 272)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (606 - 625)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (753 - 776)

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  • 1061 a.a.
Protein Preferred Names Protein Names

E3 SUMO-protein ligase ZNF451

  • E3 SUMO-protein transferase ZNF451

ZNF451 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF451 Q9Y4E5 UBE2I Homo sapiens P63279
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ruijs-Aalfs Syndrome

  • Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome

  • RJALS
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16142 ZNF451 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZNF451 MGD MGI:2137896
Rattus norvegicus ZNF451 RGD RGD:1305865
Macaca mulatta ZNF451 VGNC VGNC:79308
Felis catus ZNF451 VGNC VGNC:108381
Bos taurus ZNF451 VGNC VGNC:37279
Canis familiaris ZNF451 VGNC VGNC:48732
Others ZNF451 NCBI