Uba1 - ubiquitin-like modifier activating enzyme 1 Gene

Also Known as Sbx; A1S9; Ube-1; Ube1x

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22201

Summary

This gene encodes a member of the ubiquitin-activating E1 family. The encoded protein initiates the ubiquitin activation and transfer cascade, catalyzing the first step in ubiquitin conjugation to MARK cellular proteins for Proteasome degradation. Ubiquitin activating Enzymes use ATP to form a thioester between a conserved catalytic cysteine of the enzyme and the C-terminal carboxylate of ubiquitin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Uba1 Products (4)

mRNA Protein Name
NM_001136085.2 NP_001129557.1 ubiquitin-like modifier-activating enzyme 1 isoform 2
NM_001276316.1 NP_001263245.1 ubiquitin-like modifier-activating enzyme 1 isoform 2
NM_001276317.1 NP_001263246.1 ubiquitin-like modifier-activating enzyme 1 isoform 2
NM_009457.4 NP_033483.2 ubiquitin-like modifier-activating enzyme 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23055941 MGI
enables ubiquitin activating enzyme activity IDA
IDA: Inferred from direct assay
1511901 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin-like modifier-activating enzyme 1

  • ubiquitin-activating enzyme E1, Chr X

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-100487 TAK-243 99.86% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13297 PYZD-4409 Inhibitor 98.0% Unkown
HY-103436 NSC624206 Inhibitor 99.0% Unkown
HY-RS24221 Uba1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15319 UBA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17754 Uba1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19646 Uba2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Uba1 NCBI NCBI:7317