Ucp2 - uncoupling protein 2 (mitochondrial, proton carrier) Gene

Also Known as UCPH; UCP 2; Slc25a8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22228

Summary

Predicted to enable Oxidative Phosphorylation uncoupler activity. Involved in positive regulation of cold-induced thermogenesis and regulation of mitochondrial membrane potential. Located in mitochondrion. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system; integumental system; and nose. Used to study polycystic liver disease. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal disease; non-alcoholic fatty liver disease; and obesity. Orthologous to human UCP2 (uncoupling protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Ucp2 Products (1)

mRNA Protein Name
NM_011671.5 NP_035801.3 mitochondrial uncoupling protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GDP binding IDA
IDA: Inferred from direct assay
25127353 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
26919426 MGI
involved in long-chain fatty acid transport IDA
IDA: Inferred from direct assay
25127353 MGI
involved in macrophage differentiation IMP
IMP: Inferred from mutant phenotype
34644537 MGI
involved in mitochondrial fission IMP
IMP: Inferred from mutant phenotype
26919426 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
22956852 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
28130074 MGI
involved in reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
26919426 MGI
involved in regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
22736029 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
34644537 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial uncoupling protein 2

  • solute carrier family 25 member 8

  • uncoupling protein 2, mitochondrial

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-17389 Genipin Inhibitor 99.80% Phase 3
HY-138830 TAK-418 Inhibitor 99.81% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120160 Darglitazone Agonist 99.19% Unkown
HY-101824 NC-2100 Activator / Unkown
HY-120160A Darglitazone Sodium Agonist / Unkown
HY-RS15411 UCP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17900 Ucp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24369 Ucp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ucp2 NCBI NCBI:7351