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Cat. No.: HY-189057

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Anethole trithione derivative-1

Anethole trithione derivative-1 is a derivative of Anethole trithione (HY-B1223), and also a regulator of sulfide:quinone oxidoreductase (SQR) and uncoupling protein 2 (UCP2), with mitochondrial uncoupling-inducing activity and neuroprotective activity. Anethole trithione derivative-1 mediates mitochondrial uncoupling via SQR-dependent reverse electron transport of complex I, ROS-dependent UCP2 activation, and reduction of mitochondrial membrane potential. Anethole trithione derivative-1 reduces brain damage and improves function in mouse models of ischemic and hemorrhagic stroke. Anethole trithione derivative-1 can be used in stroke research.

For research use only. We do not sell to patients.

Formula: C₁₃H₁₁BrO₂S₃
Molecular Weight:375.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anethole trithione derivative-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
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Biological Activity

Description

IC₅₀ & Target

^[1]

IL-1β

IL-6

TNF-α

All Interleukin Related Isoforms :

All TNF Receptor Isoforms :

In Vitro

Anethole trithione derivative-1 (compound 16) (1 μM) potently reduces mitochondrial membrane potential in BV2 microglial cells via complex I RET-dependent UCP2 activation, exhibiting strong mitochondrial uncoupling activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anethole trithione derivative-1 (compound 16) (50 mg/kg; i.p.; once daily for 3 consecutive days) reduces cerebral infarction volume in a mouse model of photothrombotic ischemic stroke. It improves neurological deficits, alleviates cerebral edema, and inhibits neuroinflammation in a mouse model of intracerebral hemorrhage, and its effects in the intracerebral hemorrhage mouse model strictly depend on SQR expression in microglia and macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male mice (8-12 weeks old, 22-26 g, specific pathogen-free conditions, photothrombotic cerebral ischemia model)^[1]
Dosage:

50 mg/kg
Administration:

i.p.; daily; 3 days
Result:

Significantly reduced cerebral infarct volume compared to vehicle-treated controls.

Animal Model:

Male mice (8-12 weeks old, 22-26 g, specific pathogen-free conditions, intracerebral hemorrhage model)^[1]
Dosage:

50 mg/kg
Administration:

i.p.; daily; 3 days
Result:

Significantly decreased neuroscores compared to vehicle-treated controls.
Reduced left turn rate compared to vehicle-treated controls.
Increased right paw placement rate compared to vehicle-treated controls.
Reduced water content in the ipsilateral striatum to alleviate brain edema.
Significantly decreased protein levels of proinflammatory factors IL-1β, IL-6, and TNF-α in the ipsilateral striatum.

Animal Model:

Male microglia/macrophage-specific SQR knockout (Cx3cr1^Cre:Sqr^fl/fl) mice and littermate control Sqrfl/fl mice (8-12 weeks old, 22-26 g, specific pathogen-free conditions, intracerebral hemorrhage model)^[1]
Dosage:

50 mg/kg
Administration:

i.p.; daily; 3 days
Result:

Significantly reduced ipsilateral striatal water content relative to vehicle‑treated controls in Sqr^fl/fl mice.
Improved neurological function metrics including neuroscores, left‑turn bias and right forelimb placement accuracy relative to vehicle‑treated controls in Sqr^fl/fl mice.
Completely abolished all efficacy‑related effects in Cx3cr1^Cre:Sqr^fl/fl mice, with no significant differences observed between vehicle‑ and compound 16‑treated knockout mice.

Chemical Information

Molecular Weight 375.32
Formula C₁₃H₁₁BrO₂S₃
SMILES

COC(CCC1=C(SSC1=S)C2=CC=C(C=C2)Br)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Song P, et al. Discovery of Novel Anethole Trithione Derivatives Targeting SQR Pathway to Induce Mitochondrial Uncoupling for Stroke Treatment. Journal of medicinal chemistry. 2026 Aug 13;69(15):18764-18782.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Anethole trithione derivative-1

All Interleukin Related Isoforms

All TNF Receptor Isoforms