Unc119 - unc-119 lipid binding chaperone Gene

Also Known as Rg4; HRG4; MRG4; Rtg4; Unc119h; D11Bhm52

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22248

Summary

The protein encoded by this gene is multifunctional, affecting trafficking of transducin in rod photoreceptors, interacting with src-type tyrosine kinases through SH2 and SH3 interacting domains, and aiding the uptake of bacteria through endocytosis. In addition, the encoded protein acts as a lipid-binding chaperone to help localize some myristoylated proteins correctly. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Unc119 Products (10)

mRNA Protein Name
NM_001313985.1 NP_001300914.1 protein unc-119 homolog A isoform 1
NM_001313986.1 NP_001300915.1 protein unc-119 homolog A isoform 3
NM_001313987.1 NP_001300916.1 protein unc-119 homolog A isoform 4
NM_001313988.1 NP_001300917.1 protein unc-119 homolog A isoform 5
NM_011676.3 NP_035806.1 protein unc-119 homolog A isoform 2
NM_001313985.1 NP_001300914.1 protein unc-119 homolog A isoform 1
NM_001313986.1 NP_001300915.1 protein unc-119 homolog A isoform 3
NM_001313987.1 NP_001300916.1 protein unc-119 homolog A isoform 4
NM_001313988.1 NP_001300917.1 protein unc-119 homolog A isoform 5
NM_011676.3 NP_035806.1 protein unc-119 homolog A isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19781630 MGI
Biological Process GO Annotation Evidence References Source
involved in lipoprotein transport IMP
IMP: Inferred from mutant phenotype
21642972 MGI
involved in negative regulation of caveolin-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
19781630 MGI
involved in negative regulation of clathrin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
19781630 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein unc-119 homolog A

  • retinal gene 4

  • retinal protein 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-127002 Squarunkin A Inhibitor 99.49% Unkown
HY-164368 GLUT4 activator 2 Activator / Unkown
HY-127002A Squarunkin A hydrochloride Inhibitor / Unkown
HY-RS15462 UNC119 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15463 UNC119B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19536 Unc119 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26032 Unc119 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Unc119 NCBI NCBI:9094