1. Protein Tyrosine Kinase/RTK
  2. Src
  3. Squarunkin A hydrochloride

Squarunkin A hydrochloride 

Cat. No.: HY-127002A
Handling Instructions

Squarunkin A hydrochloride is a potent and selective UNC119-cargo interaction inhibitor (IC50 of 10 nM for inhibiting the UNC119A-myristoylated Src N-terminal peptide interaction). Squarunkin A hydrochloride interferes with the activation of Src kinase in cells.

For research use only. We do not sell to patients.

Squarunkin A hydrochloride Chemical Structure

Squarunkin A hydrochloride Chemical Structure

CAS No. : 2253744-55-5

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Description

Squarunkin A hydrochloride is a potent and selective UNC119-cargo interaction inhibitor (IC50 of 10 nM for inhibiting the UNC119A-myristoylated Src N-terminal peptide interaction). Squarunkin A hydrochloride interferes with the activation of Src kinase in cells[1].

IC50 & Target

IC50: 10 nM (UNC119A-myristoylated Src N-terminal peptide interaction)[1]

In Vitro

Squarunkin A (2.5 μM, 0.625 μM, 0.078 μM, and 0.01 μM) treatment leads to a concentration-dependent reduction of Src phosphorylation[1].
Squarunkin A does not target the lipoprotein-binding sites of other lipoprotein chaperones, such as PDE6d, AIPL1, and RhoGDI, which bind S-prenylated proteins. Squarunkin A binds to UNC119 in cell lysate and interferes with Src activation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

560.01

Formula

C₂₅H₃₃ClF₃N₅O₄

CAS No.
SMILES

O=C(N1CCC(NC2=C(NCCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3)C(C2=O)=O)CC1)OCC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Squarunkin ASrcUNC119AN-terminalmyristoylatedlipidatedphosphorylationInhibitorinhibitorinhibit

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Squarunkin A hydrochloride
Cat. No.:
HY-127002A
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