Usp9x - ubiquitin specific peptidase 9, X chromosome Gene

Also Known as Fafl; Dffrx; FAF-X; 5730589N07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22284

Summary

Enables Deubiquitinase activity and ubiquitin protein Ligase binding activity. Involved in neuron migration and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including cellular response to transforming growth factor beta stimulus; in utero embryonic development; and nervous system development. Located in apical part of cell and cytoplasm. Is expressed in several structures, including central nervous system; eye; limb interdigital region; lung; and reproductive system. Human ortholog(s) of this gene implicated in female-restricted syndromic X-linked intellectual disability 99 and non-syndromic X-linked intellectual disability 99. Orthologous to human USP9X (ubiquitin specific peptidase 9 X-linked). [provided by Alliance of Genome Resources, Apr 2022]

Usp9x Products (4)

mRNA Protein Name
NM_001408717.1 NP_001395646.1 probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform 1
NM_001408718.1 NP_001395647.1 probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform 2
NM_001408719.1 NP_001395648.1 probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform 2
NM_009481.3 NP_033507.2 probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
12895410 MGI
enables cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
30951545 MGI
enables deubiquitinase activity IDA
IDA: Inferred from direct assay
18410486 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17500595 MGI
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
18410486 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon extension IMP
IMP: Inferred from mutant phenotype
23861879 MGI
involved in axon extension IMP
IMP: Inferred from mutant phenotype
24607389 MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus IMP
IMP: Inferred from mutant phenotype
23861879 MGI
acts upstream of or within cerebellar cortex structural organization IMP
IMP: Inferred from mutant phenotype
23861879 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
23861879 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
23861879 MGI
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
24607389 MGI
acts upstream of or within neuron projection extension IGI
IGI: Inferred from genetic interaction
23861879 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
23861879 MGI
involved in protein deubiquitination IMP
IMP: Inferred from mutant phenotype
18410486 MGI
involved in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
29626158 MGI
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
31813652 MGI
involved in regulation of postsynapse assembly IEP
IEP: Inferred from expression pattern
31813652 MGI
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
31813652 MGI
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
10704870 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15509704 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
31813652 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

probable ubiquitin carboxyl-terminal hydrolase FAF-X

  • deubiquitinating enzyme FAF-X

  • fat facets homolog

  • fat facets protein-related, X-linked

  • fats facets protein related, X

  • ubiquitin carboxyl-terminal hydrolase FAM

  • ubiquitin thioesterase FAF-X

  • ubiquitin thiolesterase FAF-X

  • ubiquitin-specific protease 9,

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13264 Degrasyn 99.70% Unkown
HY-145967 FT709 Inhibitor 99.81% Unkown
HY-111408 EOAI3402143 Inhibitor 98.11% Unkown
HY-149230 USP28-IN-4 Inhibitor 98.86% Unkown
HY-149229 USP28-IN-3 Inhibitor 98.26% Unkown
HY-RS15570 USP9X Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-149228 USP28-IN-2 Inhibitor / Unkown
HY-RS16960 Usp9x Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23403 Usp9x Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Usp9x NCBI NCBI:8239