Vamp8 - vesicle-associated membrane protein 8 Gene

Also Known as Edb; endobrevin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22320

Summary

Predicted to enable SNAP receptor activity; Chloride Channel Inhibitor activity; and syntaxin binding activity. Involved in SNARE complex assembly and mucus secretion. Acts upstream of or within several processes, including cellular response to interferon-gamma; positive regulation of pancreatic amylase secretion; and zymogen granule exocytosis. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and lysosome. Part of SNARE complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human VAMP8 (vesicle associated membrane protein 8). [provided by Alliance of Genome Resources, Apr 2022]

Vamp8 Products (1)

mRNA Protein Name
NM_016794.3 NP_058074.2 vesicle-associated membrane protein 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14668490 MGI
Biological Process GO Annotation Evidence References Source
involved in SNARE complex assembly IDA
IDA: Inferred from direct assay
21151919 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
19144319 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
18535671 MGI
involved in mucus secretion IMP
IMP: Inferred from mutant phenotype
22144578 MGI
acts upstream of or within positive regulation of pancreatic amylase secretion IMP
IMP: Inferred from mutant phenotype
18535671 MGI
acts upstream of or within regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
18227281 MGI
acts upstream of or within vesicle fusion IMP
IMP: Inferred from mutant phenotype
18535671 MGI
acts upstream of or within zymogen granule exocytosis IMP
IMP: Inferred from mutant phenotype
18535671 MGI
Cellular Component GO Annotation Evidence References Source
part of SNARE complex IDA
IDA: Inferred from direct assay
18535671 MGI
located in basal part of cell IDA
IDA: Inferred from direct assay
18535671 MGI
located in basolateral part of cell IDA
IDA: Inferred from direct assay
18535671 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
18535671 MGI
located in cell surface IDA
IDA: Inferred from direct assay
21151919 MGI
located in cytosol IDA
IDA: Inferred from direct assay
22589474 MGI
located in lysosome IDA
IDA: Inferred from direct assay
27628032 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
19144319 MGI
located in secretory granule IDA
IDA: Inferred from direct assay
18321981 MGI
located in zymogen granule IDA
IDA: Inferred from direct assay
18535671 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vesicle-associated membrane protein 8

  • VAMP-8

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P10809 VAMP Inhibitor 98.13% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15599 VAMP8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19045 Vamp8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25535 Vamp8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vamp8 NCBI NCBI:8673