Wars1 - tryptophanyl-tRNA synthetase1 Gene

Also Known as WRS; Wars; TrpRS

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22375

Summary

Enables tryptophan-tRNA Ligase activity. Involved in tryptophanyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in distal hereditary motor neuronopathy type 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Wars1 Products (7)

mRNA Protein Name
NM_001164314.2 NP_001157786.1 tryptophan--tRNA ligase, cytoplasmic isoform 2
NM_001164488.2 NP_001157960.1 tryptophan--tRNA ligase, cytoplasmic isoform 2
NM_001411907.1 NP_001398836.1 tryptophan--tRNA ligase, cytoplasmic isoform 1
NM_001411908.1 NP_001398837.1 tryptophan--tRNA ligase, cytoplasmic isoform 1
NM_001411909.1 NP_001398838.1 tryptophan--tRNA ligase, cytoplasmic isoform 1
NM_001411910.1 NP_001398839.1 tryptophan--tRNA ligase, cytoplasmic isoform 3
NM_011710.4 NP_035840.3 tryptophan--tRNA ligase, cytoplasmic isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables tryptophan-tRNA ligase activity IDA
IDA: Inferred from direct assay
19941862 MGI
enables tryptophan-tRNA ligase activity IMP
IMP: Inferred from mutant phenotype
12060739 MGI
Biological Process GO Annotation Evidence References Source
involved in tryptophanyl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
12060739 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tryptophan--tRNA ligase, cytoplasmic

  • tryptophanyl-tRNA synthetase, cytoplasmic

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15739 WARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19754 Wars1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26251 Wars1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wars1 NCBI NCBI:7453