Pi4ka - phosphatidylinositol 4-kinase alpha Gene

Also Known as Pik4ca

Species: Mus musculus

Gene Type: protein coding
Gene ID: 224020

About Pi4ka

Chromosome 16: 17,098,215-17,224,178 reverse strand.GRCm39:CM001009.3

This gene has 11 transcripts (splice variants), 210 orthologues, 9 paralogues and is associated with 13 phenotypes. Ubiquitous expression in cortex adult (RPKM 25.4), frontal lobe adult (RPKM 25.2) and 28 other tissues.

Summary

Enables 1-phosphatidylinositol 4-kinase activity. Involved in phosphatidylinositol phosphate biosynthetic process. Predicted to be located in Golgi-associated vesicle membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PI4KA (phosphatidylinositol 4-kinase alpha). [provided by Alliance of Genome Resources, Apr 2022]

Pi4ka Products (2)

mRNA Protein Name
NM_001001983.2 NP_001001983.2 phosphatidylinositol 4-kinase alpha isoform 2
NM_001373955.1 NP_001360884.1 phosphatidylinositol 4-kinase alpha isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 1-phosphatidylinositol 4-kinase activity IMP
IMP: Inferred from mutant phenotype
23229899 MGI
Biological Process GO Annotation Evidence References Source
involved in phosphatidylinositol phosphate biosynthetic process IMP
IMP: Inferred from mutant phenotype
23229899 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pi4ka Protein Structure

PI4K_N

PI4K_N: cl44709 (380 - 1516)

PI4Ka

PI4Ka: cd00871 (1549 - 1724)

PI4Kc_III_alpha

PI4Kc_III_alpha: cd05167 (1785 - 2103)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2105 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4-kinase alpha

  • PI4-kinase alpha

  • PI4K-alpha

  • phosphatidylinositol 4-kinase, catalytic, alpha polypeptide

  • ptdIns-4-kinase alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125118 GSK-A1 Inhibitor 99.04% Unkown
HY-100603 GSK-F1 Inhibitor 95.06% Unkown
HY-RS10466 PI4KA Human Pre-designed siRNA Set A / Unkown
HY-RS10467 Pi4ka Mouse Pre-designed siRNA Set A / Unkown
HY-RS10468 Pi4ka Rat Pre-designed siRNA Set A / Unkown
HY-100603B (R)-GSK-F1 Inhibitor / Unkown
HY-148956 PI4KA-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pi4ka NCBI NCBI:5297