Pi4ka - phosphatidylinositol 4-kinase alpha Gene

Mus musculus

Also known as Pik4ca

Gene ID: 224020 | Gene type: protein coding

About Pi4ka

Chromosome 16: 17,098,215-17,224,178 reverse strand.GRCm39:CM001009.3

This gene has 11 transcripts (splice variants), 210 orthologues, 9 paralogues and is associated with 13 phenotypes. Ubiquitous expression in cortex adult (RPKM 25.4), frontal lobe adult (RPKM 25.2) and 28 other tissues.

Summary

Enables 1-phosphatidylinositol 4-kinase activity. Involved in phosphatidylinositol phosphate biosynthetic process. Predicted to be located in Golgi-associated vesicle membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PI4KA (phosphatidylinositol 4-kinase alpha). [provided by Alliance of Genome Resources, Apr 2022]

Pi4ka Products(2)

mRNA	Protein	Name
NM_001001983.2	NP_001001983.2	phosphatidylinositol 4-kinase alpha isoform 2
NM_001373955.1	NP_001360884.1	phosphatidylinositol 4-kinase alpha isoform 1

Pi4ka Protein Structure

PI4K_N

PI4Ka

PI4Kc_III_alpha

0
400
800
1200
1600
2000
2105 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 4-kinase alpha

PI4-kinase alpha	PI4K-alpha
phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	ptdIns-4-kinase alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125118	GSK-A1	Inhibitor	≥99.0%	Unkown
HY-100603	GSK-F1		95.00%	Unkown
HY-RS10466	PI4KA Human Pre-designed siRNA Set A		/	Unkown
HY-RS10467	Pi4ka Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS10468	Pi4ka Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pi4ka	NCBI	NCBI:5297

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