Wnt1 - wingless-type MMTV integration site family, member 1 Gene

Also Known as sw; Int-1; Wnt-1; swaying

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22408

Summary

Enables cytokine activity and protein domain specific binding activity. Involved in several processes, including astrocyte-dopaminergic neuron signaling; central nervous system development; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; regulation of cellular protein metabolic process; and ubiquitin-dependent SMAD protein catabolic process. Located in cell surface and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo ectoderm; and genitourinary system. Used to study breast Cancer. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15 and osteoporosis. Orthologous to human Wnt1 (Wnt family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Wnt1 Products (1)

mRNA Protein Name
NM_021279.4 NP_067254.1 proto-oncogene Wnt-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
10557084 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10866835 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
15454084 MGI
enables receptor ligand activity IDA
IDA: Inferred from direct assay
10557084 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
11029007 MGI
Biological Process GO Annotation Evidence References Source
involved in Spemann organizer formation IMP
IMP: Inferred from mutant phenotype
9192640 MGI
acts upstream of or within T cell differentiation in thymus IDA
IDA: Inferred from direct assay
11265645 MGI
involved in Wnt signaling pathway IDA
IDA: Inferred from direct assay
9192640 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IGI
IGI: Inferred from genetic interaction
16054034 MGI
acts upstream of or within canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
9652750 MGI
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
12121999 MGI
acts upstream of or within canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
15143170 MGI
acts upstream of cell population proliferation IDA
IDA: Inferred from direct assay
9160667 MGI
involved in cell proliferation in midbrain IDA
IDA: Inferred from direct assay
14557550 MGI
involved in cell-cell signaling IDA
IDA: Inferred from direct assay
10557084 MGI
involved in central nervous system morphogenesis IMP
IMP: Inferred from mutant phenotype
2202907 MGI
involved in cerebellum development IMP
IMP: Inferred from mutant phenotype
8848044 MGI
involved in cerebellum formation IMP
IMP: Inferred from mutant phenotype
2202907 MGI
acts upstream of or within diencephalon development IGI
IGI: Inferred from genetic interaction
18094027 MGI
involved in dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
23324743 MGI
involved in embryonic axis specification IMP
IMP: Inferred from mutant phenotype
2534596 MGI
involved in embryonic brain development IDA
IDA: Inferred from direct assay
15121182 MGI
acts upstream of fat cell differentiation IDA
IDA: Inferred from direct assay
15728361 MGI
acts upstream of or within forebrain anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
18094027 MGI
acts upstream of hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
9160667 MGI
acts upstream of or within hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
9160667 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
15961523 MGI
acts upstream of or within metencephalon development IMP
IMP: Inferred from mutant phenotype
2205396 MGI
involved in midbrain development IDA
IDA: Inferred from direct assay
14557550 MGI
acts upstream of or within midbrain development IMP
IMP: Inferred from mutant phenotype
2205396 MGI
involved in midbrain development IMP
IMP: Inferred from mutant phenotype
2202907 MGI
involved in midbrain dopaminergic neuron differentiation IDA
IDA: Inferred from direct assay
19951692 MGI
involved in midbrain dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
23324743 MGI
acts upstream of or within midbrain-hindbrain boundary development IMP
IMP: Inferred from mutant phenotype
2205396 MGI
acts upstream of or within midbrain-hindbrain boundary maturation during brain development IMP
IMP: Inferred from mutant phenotype
8555108 MGI
acts upstream of or within myoblast fusion IDA
IDA: Inferred from direct assay
15282335 MGI
acts upstream of or within myoblast fusion IGI
IGI: Inferred from genetic interaction
15282335 MGI
acts upstream of or within myotube differentiation IGI
IGI: Inferred from genetic interaction
15282335 MGI
involved in negative regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
9473323 MGI
acts upstream of or within negative regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
10937998 MGI
involved in negative regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
10937998 MGI
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
21752258 MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
16601693 MGI
acts upstream of or within negative regulation of ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
16601693 MGI
involved in neurogenesis IDA
IDA: Inferred from direct assay
14557550 MGI
acts upstream of or within neuron fate commitment IMP
IMP: Inferred from mutant phenotype
16339193 MGI
acts upstream of or within neuron fate determination IMP
IMP: Inferred from mutant phenotype
16339193 MGI
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15035989 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9356179 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12937339 MGI
acts upstream of or within positive regulation of hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
9160667 MGI
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
15143170 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9769173 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19951692 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15574752 MGI
acts upstream of or within spinal cord association neuron differentiation IGI
IGI: Inferred from genetic interaction
11877374 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
8710372 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
11336703 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proto-oncogene Wnt-1

  • proto-oncogene Int-1

  • proto-oncogene protein Wnt-1

  • wingless-related MMTV integration site 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-164528 SJ26 Inhibitor 98.65% Unkown
HY-184895 CM002 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wnt1 NCBI NCBI:7471