Ybx1 - Y box protein 1 Gene

Also Known as EF1A; MSY1; YB-1; dbpB; Nsep1; mYB-1a; 1700102N10Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22608

Summary

Enables chromatin binding activity; mRNA binding activity; and single-stranded DNA binding activity. Involved in epidermis development and negative regulation of cellular senescence. Acts upstream of or within several processes, including cellular response to interleukin-7; negative regulation of striated muscle cell differentiation; and negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of histone pre-mRNA 3'end processing complex. Is expressed in several structures, including branchial arch; central nervous system; facial prominence; gonad; and retina. Orthologous to human YBX1 (Y-box binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ybx1 Products (1)

mRNA	Protein	Name
NM_011732.2	NP_035862.2	Y-box-binding protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	24788519	MGI
enables mRNA binding	IDA IDA: Inferred from direct assay	20713358	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8871564	MGI
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	15282343	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to interleukin-7	IDA IDA: Inferred from direct assay	29581031	MGI
involved in epidermis development	IMP IMP: Inferred from mutant phenotype	29712925	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	16954378	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	16954378	MGI
involved in negative regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	29712925	MGI
acts upstream of or within negative regulation of striated muscle cell differentiation	IDA IDA: Inferred from direct assay	20004191	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20004191	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20004191	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20713358	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	20713358	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	20004191	MGI
part of histone pre-mRNA 3'end processing complex	IDA IDA: Inferred from direct assay	19470752	MGI
located in nucleus	IDA IDA: Inferred from direct assay	20713358	MGI
located in nucleus	IGI IGI: Inferred from genetic interaction	20004191	MGI
is active in synapse	EXP EXP: Inferred from Experiment	25211037	MGI
is active in synapse	IDA IDA: Inferred from direct assay	25211037	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
Y-box-binding protein 1	CBF-A CCAAT-binding transcription factor I subunit A DNA-binding protein B EFI-A Y-box transcription factor enhancer factor I subunit A nuclease-sensitive element-binding protein 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15916	YBX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16252	Ybx1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181098	FKA-9i		/	Unkown
HY-RS23592	Ybx1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ybx1	NCBI	NCBI:4904