Ywhae - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22627

Summary

Enables protein domain specific binding activity and protein Phosphatase binding activity. Acts upstream of or within several processes, including negative regulation of protein dephosphorylation; neuron migration; and pallium development. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study Miller-Dieker lissencephaly syndrome and left ventricular noncompaction. Orthologous to human YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon). [provided by Alliance of Genome Resources, Apr 2022]

Ywhae Products (1)

mRNA Protein Name
NM_009536.4 NP_033562.3 14-3-3 protein epsilon

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11585834 MGI
enables protein domain specific binding IDA
IDA: Inferred from direct assay
12446771 MGI
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
23326474 MGI
enables protein phosphatase inhibitor activity IDA
IDA: Inferred from direct assay
12796778 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cerebral cortex development IMP
IMP: Inferred from mutant phenotype
12796778 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
12796778 MGI
acts upstream of or within neuron migration IGI
IGI: Inferred from genetic interaction
12796778 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
12796778 MGI
acts upstream of or within protein targeting IDA
IDA: Inferred from direct assay
12446771 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23326474 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

14-3-3 protein epsilon

  • 14-3-3 epsilon

  • 14-3-3E

  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide

Recombinant Ywhae Proteins

Cat. No. Product Name Accession Purity
HY-P75549 14-3-3 epsilon Protein, Mouse (His) P62259 (M1-Q255) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-180371 NF-115 Inducer / Unkown
HY-RS15941 YWHAE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17845 Ywhae Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24313 Ywhae Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ywhae NCBI NCBI:7531