Zbtb7b - zinc finger and BTB domain containing 7B Gene

Also Known as Thpok; Zfp67; c-Krox

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22724

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and regulation of alpha-beta T cell activation. Acts upstream of or within regulation of alpha-beta T cell differentiation and regulation of gene expression. Located in nucleus. Is expressed in several structures, including alimentary system; forebrain; genitourinary system; sensory organ; and skin. Orthologous to human ZBTB7B (zinc finger and BTB domain containing 7B). [provided by Alliance of Genome Resources, Apr 2022]

Zbtb7b Products (8)

mRNA Protein Name
NM_001355206.2 NP_001342135.2 zinc finger and BTB domain-containing protein 7B
NM_001355211.2 NP_001342140.1 zinc finger and BTB domain-containing protein 7B
NM_001355212.2 NP_001342141.1 zinc finger and BTB domain-containing protein 7B
NM_001410678.1 NP_001397607.1 zinc finger and BTB domain-containing protein 7B
NM_001410679.1 NP_001397608.1 zinc finger and BTB domain-containing protein 7B
NM_001410680.1 NP_001397609.1 zinc finger and BTB domain-containing protein 7B
NM_001410681.1 NP_001397610.1 zinc finger and BTB domain-containing protein 7B
NM_009565.6 NP_033591.2 zinc finger and BTB domain-containing protein 7B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
7937772 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
7937772 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
8702912 MGI
enables DNA-binding transcription repressor activity IMP
IMP: Inferred from mutant phenotype
22730529 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7937772 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8702912 MGI
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
22730529 MGI
enables identical protein binding IDA
IDA: Inferred from direct assay
8702912 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
22730529 MGI
Biological Process GO Annotation Evidence References Source
involved in NK T cell differentiation IMP
IMP: Inferred from mutant phenotype
23105140 MGI
involved in adaptive thermogenesis IMP
IMP: Inferred from mutant phenotype
28784777 MGI
involved in lactation IMP
IMP: Inferred from mutant phenotype
29420538 MGI
involved in negative regulation of CD8-positive, alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
22730529 MGI
involved in negative regulation of NK T cell proliferation IMP
IMP: Inferred from mutant phenotype
23105140 MGI
acts upstream of or within negative regulation of T-helper 17 cell differentiation IMP
IMP: Inferred from mutant phenotype
23034280 MGI
acts upstream of or within negative regulation of gene expression IDA
IDA: Inferred from direct assay
23034280 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22730529 MGI
involved in positive regulation of CD4-positive, alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
24880459 MGI
involved in positive regulation of SREBP signaling pathway IMP
IMP: Inferred from mutant phenotype
29420538 MGI
involved in positive regulation of brown fat cell differentiation IMP
IMP: Inferred from mutant phenotype
28784777 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
28784777 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
21357543 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
24880459 MGI
involved in positive regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
29420538 MGI
involved in positive regulation of interleukin-17 production IMP
IMP: Inferred from mutant phenotype
23105140 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7937772 MGI
acts upstream of or within regulation of CD8-positive, alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
18776904 MGI
acts upstream of or within regulation of T-helper cell differentiation IMP
IMP: Inferred from mutant phenotype
18776904 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23034280 MGI
involved in response to insulin IMP
IMP: Inferred from mutant phenotype
29420538 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
29420538 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger and BTB domain-containing protein 7B

  • T-helper-inducing POZ/Krueppel-like factor

  • Vzinc finger and BTB domain containing 7B

  • krueppel-related zinc finger protein cKrox

  • zinc finger protein 67

  • zinc finger protein Th-POK

Zbtb7b Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Zbtb7b Q64321 Tmpo Mus musculus Q61029
Anti Bait CoIP
22726435
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15980 ZBTB7B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zbtb7b NCBI NCBI:51043