Ikzf4 - IKAROS family zinc finger 4 Gene

Also Known as Eos; Zfpn1a4; Znfn1a4; A630026H08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22781

Summary

Enables bHLH transcription factor binding activity; identical protein binding activity; and sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription, DNA-templated and positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body. Predicted to be part of protein-containing complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; hemolymphoid system; and retina. Used to study encephalomyelitis. Orthologous to human IKZF4 (IKAROS family zinc finger 4). [provided by Alliance of Genome Resources, Apr 2022]

Ikzf4 Products (3)

mRNA Protein Name
NM_001358536.1 NP_001345465.1 zinc finger protein Eos isoform 2
NM_001358537.1 NP_001345466.1 zinc finger protein Eos isoform 2
NM_011772.3 NP_035902.2 zinc finger protein Eos isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables bHLH transcription factor binding IPI
IPI: Inferred from physical interaction
22638570 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12444977 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
22638570 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of DNA-templated transcription IPI
IPI: Inferred from physical interaction
12444977 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22638570 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger protein Eos

  • ikaros family zinc finger protein 4

  • zinc finger protein, subfamily 1A, 4 (Eos)

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-173630 BMS-986449 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-144998 NVP-DKY709 Inhibitor 99.66% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ikzf4 NCBI NCBI:64375