Otud7b - OTU domain containing 7B Gene

Also Known as Za20d1; CEZANNE; Trabid2; 2900060B22Rik; 4930463P07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 229603

Summary

Enables K63-linked polyubiquitin modification-dependent protein binding activity and thiol-dependent Deubiquitinase. Involved in several processes, including negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of transcription by RNA polymerase II; and protein K48-linked deubiquitination. Acts upstream of or within in utero embryonic development and protein deubiquitination. Located in cytoplasm. Orthologous to human OTUD7B (OTU Deubiquitinase 7B). [provided by Alliance of Genome Resources, Apr 2022]

Otud7b Products (2)

mRNA Protein Name
NM_001025613.1 NP_001020784.1 OTU domain-containing protein 7B
NM_001025614.1 NP_001020785.1 OTU domain-containing protein 7B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables K63-linked polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
18281465 MGI
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
12682062 MGI
enables cysteine-type deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
23334419 MGI
enables cysteine-type peptidase activity IMP
IMP: Inferred from mutant phenotype
23334419 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18281465 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
27996060 MGI
involved in mucosal immune response IMP
IMP: Inferred from mutant phenotype
23334419 MGI
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
23334419 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21097510 MGI
involved in protein K48-linked deubiquitination IMP
IMP: Inferred from mutant phenotype
23334419 MGI
acts upstream of or within protein deubiquitination IDA
IDA: Inferred from direct assay
12682062 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12682062 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

OTU domain-containing protein 7B

  • TRAF binding domain containing 2

  • cellular zinc finger anti-NF-kappa-B protein

  • zinc finger A20 domain-containing protein 1

  • zinc finger protein Cezanne

  • zinc finger, A20 domain containing 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09877 OTUD7B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20186 Otud7b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26690 Otud7b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Otud7b NCBI NCBI:56957