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RAB21 - RAB21, member RAS oncogene family Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23011

About RAB21

Cytogenetic location: 12q21.1 Genomic coordinates (GRCh38): 12:71,754,863-71,800,286 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 68 paralogues. Ubiquitous expression in kidney (RPKM 10.9), adrenal (RPKM 10.2) and 25 other tissues.

Summary

This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with Integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015]

RAB21 Products (1)

mRNA	Protein	Name
NM_014999.4	NP_055814.1	ras-related protein Rab-21

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GDP binding	IDA IDA: Inferred from direct assay	16034420	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	16034420	GOA
enables GTP binding	IMP IMP: Inferred from mutant phenotype	15561770	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	16034420	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16525121	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in anterograde axonal transport	IDA IDA: Inferred from direct assay	22705394	GOA
involved in anterograde axonal transport	IMP IMP: Inferred from mutant phenotype	22705394	GOA
involved in positive regulation of early endosome to late endosome transport	IMP IMP: Inferred from mutant phenotype	15561770	GOA
involved in positive regulation of receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	15561770	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	31455601	GOA
involved in regulation of exocytosis	IDA IDA: Inferred from direct assay	22705394	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi cisterna membrane	IDA IDA: Inferred from direct assay	15561770	GOA
located in cytoplasmic side of early endosome membrane	IDA IDA: Inferred from direct assay	15561770	GOA
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	15561770	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	19745841	GOA
located in vesicle membrane	IDA IDA: Inferred from direct assay	15561770	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB21 Protein Structure

Ras

0
100
200
225 a.a.

Protein Preferred Names	Protein Names
ras-related protein Rab-21	GTP-binding protein RAB21

RAB21 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAB21	Q9UL25	APPL1	Homo sapiens	Q9UKG1	Pull Down	17581628

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Carpenter Syndrome 1	Carpenter Syndrome Acrocephalopolysyndactyly Type Ii Acps Ii CRPT1 Acrocephalopolysyndactyly Type 2 Acrocephalosyndactyly, Type Ii Acrocephalopolysyndactyly 2 Acps2 Acps 2 Type Ii Acrocephalosyndactyly Carpenter Syndrome, Type 1 Apert-Crouzon Disease
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii
Charcot-Marie-Tooth Disease, Type 4b2	Charcot-Marie-Tooth Disease Type 4b2 CMT4B2 Charcot-Marie-Tooth Disease, With Focally Folded Myelin Sheaths, Autosomal Recessive, Type 4b2 Charcot-Marie-Tooth Neuropathy, Type 4b2 Charcot-Marie-Tooth Neuropathy Type 4b2 Autosomal Recessive Charcot-Marie-Tooth Disease With Focally Folded Myelin Sheaths Type 4b2 Cmt 4b2 Charcot Marie Tooth Disease Type 4b2 Charcot-Marie-Tooth Disease 4b2 Charcot-Marie-Tooth Disease Autosomal Recessive With Focally Folded Myelin Sheaths 4b2 Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4b2
Warburg Micro Syndrome 1	Warburg Micro Syndrome Micro Syndrome Warbm WARBM1 Warburg Sjo Fledelius Syndrome Warburg-Sjo-Fledelius Syndrome Micro Syndrome 1 Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS22759	Rab21 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11531	RAB21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29273	Rab21 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RAB21	VGNC	VGNC:33628
Rattus norvegicus	RAB21	RGD	RGD:1303150
Macaca mulatta	RAB21	VGNC	VGNC:100097
Mus musculus	RAB21	MGD	MGI:894308
Canis familiaris	RAB21	VGNC	VGNC:45261
Others	RAB21	NCBI