PDZD2 - PDZ domain containing 2 Gene

Also Known as AIPC; PIN1; PAPIN; PDZK3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23037

About PDZD2

Cytogenetic location: 5p13.3 Genomic coordinates (GRCh38): 5:31,639,131-32,110,932 (from NCBI)

This gene has 12 transcripts (splice variants), 230 orthologues and 1 paralogue. Biased expression in fat (RPKM 15.3), ovary (RPKM 9.0) and 12 other tissues.

Summary

The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a Caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Dec 2015]

PDZD2 Products (1)

mRNA Protein Name
NM_178140.4 NP_835260.2 PDZ domain-containing protein 2

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11289102 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDZD2 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (338 - 415)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (590 - 664)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (752 - 810)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (2624 - 2692)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (2756 - 2833)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2500
  • 2839 a.a.
Protein Preferred Names Protein Names

PDZ domain-containing protein 2

  • PDZ domain-containing protein 3

Related Diseases

Diseases Alias
Motility-Related Diarrhea
Sacral Defect With Anterior Meningocele

  • Caudal Regression Syndrome

  • Caudal Regression Sequence

  • Sacral Agenesis

  • Caudal Dysgenesis Syndrome

  • SDAM

  • Caudal Dysplasia Sequence

  • Caudal Dysplasia

  • Sacral Agenesis Syndrome

  • Sacral Regression Syndrome

  • Sacral Defect And Anterior Sacral Meningocele

  • Rudd Klimek Syndrome

  • Sirenomelia
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10301 PDZD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22716 Pdzd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29230 Pdzd2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PDZD2 MGD MGI:1922394
Bos taurus PDZD2 VGNC VGNC:32725
Rattus norvegicus PDZD2 RGD RGD:619958
Felis catus PDZD2 VGNC VGNC:64100
Macaca mulatta PDZD2 VGNC VGNC:75829
Others PDZD2 NCBI