country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

PDZD2 - PDZ domain containing 2 Gene

Also Known as AIPC; PIN1; PAPIN; PDZK3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23037

About PDZD2

Cytogenetic location: 5p13.3 Genomic coordinates (GRCh38): 5:31,639,131-32,110,932 (from NCBI)

This gene has 12 transcripts (splice variants), 230 orthologues and 1 paralogue. Biased expression in fat (RPKM 15.3), ovary (RPKM 9.0) and 12 other tissues.

Summary

The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a Caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Dec 2015]

PDZD2 Products (1)

mRNA	Protein	Name
NM_178140.4	NP_835260.2	PDZ domain-containing protein 2

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11289102	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDZD2 Protein Structure

PDZ

0
500
1000
1500
2000
2500
2839 a.a.

Protein Preferred Names	Protein Names
PDZ domain-containing protein 2	PDZ domain-containing protein 3

Related Diseases

Diseases	Alias
Motility-Related Diarrhea
Sacral Defect With Anterior Meningocele	Caudal Regression Syndrome Caudal Regression Sequence Sacral Agenesis Caudal Dysgenesis Syndrome SDAM Caudal Dysplasia Sequence Caudal Dysplasia Sacral Agenesis Syndrome Sacral Regression Syndrome Sacral Defect And Anterior Sacral Meningocele Rudd Klimek Syndrome Sirenomelia
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10301	PDZD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22716	Pdzd2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PDZD2	MGD	MGI:1922394
Bos taurus	PDZD2	VGNC	VGNC:32725
Rattus norvegicus	PDZD2	RGD	RGD:619958
Felis catus	PDZD2	VGNC	VGNC:64100
Macaca mulatta	PDZD2	VGNC	VGNC:75829