Kmt2c - lysine (K)-specific methyltransferase 2C Gene

Also Known as HALR; Mll3; E330008K23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 231051

Summary

Predicted to enable histone binding activity; Histone Methyltransferase activity (H3-K4 specific); and transcription coactivator activity. Involved in histone methylation. Acts upstream of or within several processes, including eyelid development in camera-type eye; positive regulation of fibroblast proliferation; and single fertilization. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. Is expressed in several structures, including eye; genitourinary system; limb; nervous system; and neural ectoderm. Human ortholog(s) of this gene implicated in Klatskin's tumor; Kleefstra syndrome 2; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human KMT2C (lysine methyltransferase 2C). [provided by Alliance of Genome Resources, Apr 2022]

Kmt2c Products (2)

mRNA Protein Name
NM_001081383.2 NP_001074852.1 histone-lysine N-methyltransferase 2C
NM_001081383.2 NP_001074852.1 histone-lysine N-methyltransferase 2C

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables histone H3K4 methyltransferase activity IDA
IDA: Inferred from direct assay
18172164 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17021013 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within eyelid development in camera-type eye IMP
IMP: Inferred from mutant phenotype
17021013 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
17021013 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
17021013 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17021013 MGI
acts upstream of or within single fertilization IMP
IMP: Inferred from mutant phenotype
17021013 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase 2C

  • histone-lysine N-methyltransferase MLL3

  • myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07403 KMT2C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26552 Kmt2c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20048 Kmt2c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kmt2c NCBI NCBI:58508