Tnip2 - TNFAIP3 interacting protein 2 Gene

Also Known as ABIN-2; 1810020H16Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 231130

Summary

Predicted to enable polyubiquitin modification-dependent protein binding activity and protein kinase binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of leukocyte activation; and Toll-like Receptor signaling pathway. Acts upstream of or within I-kappaB kinase/NF-kappaB signaling. Located in cytoplasm. Orthologous to human TNIP2 (TNFAIP3 interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Tnip2 Products (1)

mRNA	Protein	Name
NM_139064.2	NP_620703.1	TNFAIP3-interacting protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IDA IDA: Inferred from direct assay	11390377	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20060382	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in CD40 signaling pathway	IMP IMP: Inferred from mutant phenotype	16633345	MGI
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	16633345	MGI
involved in interleukin-1-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	16633345	MGI
acts upstream of or within negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	11390377	MGI
involved in positive regulation of B cell activation	IMP IMP: Inferred from mutant phenotype	16633345	MGI
involved in positive regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	16633345	MGI
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	16633345	MGI
involved in toll-like receptor 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	16633345	MGI
involved in toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	16633345	MGI
involved in toll-like receptor 9 signaling pathway	IMP IMP: Inferred from mutant phenotype	16633345	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	11390377	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
TNFAIP3-interacting protein 2	A20 binding inhibitor of NF-kappaB activation-2 A20-binding inhibitor of NF-kappa-B activation 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14835	TNIP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22867	Tnip2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29381	Tnip2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tnip2	NCBI	NCBI:79155