Cnot1 - CCR4-NOT transcription complex, subunit 1 Gene

Also Known as D830048B13; 6030411K04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 234594

Summary

Predicted to enable armadillo repeat domain binding activity; molecular adaptor activity; and nuclear receptor binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Involved in regulation of stem cell population maintenance and trophectodermal cell differentiation. Located in P-body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in holoprosencephaly. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Cnot1 Products (5)

mRNA Protein Name
NM_001205226.2 NP_001192155.1 CCR4-NOT transcription complex subunit 1 isoform 3
NM_001372351.1 NP_001359280.1 CCR4-NOT transcription complex subunit 1 isoform 4
NM_001372353.1 NP_001359282.1 CCR4-NOT transcription complex subunit 1 isoform 5
NM_153164.4 NP_694804.3 CCR4-NOT transcription complex subunit 1 isoform 1
NM_178078.3 NP_835179.1 CCR4-NOT transcription complex subunit 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17452450 MGI
Biological Process GO Annotation Evidence References Source
involved in regulation of stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
22367759 MGI
involved in trophectodermal cell differentiation IMP
IMP: Inferred from mutant phenotype
22367759 MGI
Cellular Component GO Annotation Evidence References Source
located in P-body IDA
IDA: Inferred from direct assay
20133598 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CCR4-NOT transcription complex subunit 1

  • CCR4-associated factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS22450 Cnot1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02899 CNOT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28973 Cnot1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cnot1 NCBI NCBI:23019