SRRM2 - serine/arginine repetitive matrix 2 Gene

Also Known as CWF21; Cwc21; 300-KD; SRL300; SRm300; HSPC075

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23524

About SRRM2

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,752,638-2,771,412 (from NCBI)

This gene has 27 transcripts (splice variants), 131 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 88.4), bone marrow (RPKM 86.9) and 25 other tissues.

Summary

Enables C2H2 zinc finger domain binding activity and protein N-terminus binding activity. Involved in mRNA splicing, via spliceosome. Located in Cajal body and nuclear speck. Part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceosome. Biomarker of Parkinson's disease. [provided by Alliance of Genome Resources, Apr 2022]

SRRM2 Products (1)

mRNA	Protein	Name
NM_016333.4	NP_057417.3	serine/arginine repetitive matrix protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables C2H2 zinc finger domain binding	IDA IDA: Inferred from direct assay	17577209	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17577209	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Cajal body	IDA IDA: Inferred from direct assay	17577209	GOA
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	29361316	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	17577209	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28062851	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRRM2 Protein Structure

cwf21

0
500
1000
1500
2000
2500
2752 a.a.

Protein Preferred Names	Protein Names
serine/arginine repetitive matrix protein 2	300 kDa nuclear matrix antigen

Related Diseases

Diseases	Alias
Status Epilepticus	Grand Mal Status Epilepticus Grand Mal Status Gcse Generalized Convulsive Status Epilepticus Se Epilepsy With Status Epilepticus
Patella, Chondromalacia Of	Chondromalacia Patellae Chondromalacia Of Patella Softening Of Articular Cartilage Of Patella Patellofemoral Pain Syndrome Patellofemoral Chondromalacia
Idh-Mutant Anaplastic Astrocytoma
Dicer1 Syndrome	Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility Syndrome Pleuropulmonary Blastoma Familial Tumor Susceptibility Syndrome Ppb Familial Tumor Susceptibility Syndrome Dicer1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility Dicer1-Related Pleuropulmonary Blastoma Pleuropulmonary Blastoma Familial Tumor And Dysplasia Syndrome Pleuropulmonary Blastoma Family Tumor Susceptibility Syndrome Ppbftds Doid:0081063

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13787	SRRM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18843	Srrm2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25335	Srrm2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SRRM2	VGNC	VGNC:58613
Rattus norvegicus	SRRM2	RGD	RGD:1310163
Felis catus	SRRM2	VGNC	VGNC:65691
Macaca mulatta	SRRM2	VGNC	VGNC:82248
Canis familiaris	SRRM2	VGNC	VGNC:54071
Mus musculus	SRRM2	MGD	MGI:1923206
Others	SRRM2	NCBI