Zbtb16 - zinc finger and BTB domain containing 16 Gene

Also Known as lu; PLZF; Zfp145

Species: Mus musculus

Gene Type: protein coding
Gene ID: 235320

Summary

Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; protein C-terminus binding activity; and protein homodimerization activity. Involved in animal organ development; central nervous system development; and regulation of hemopoiesis. Acts upstream of or within several processes, including embryonic pattern specification; limb morphogenesis; and male germ-line stem cell asymmetric division. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human ZBTB16 (zinc finger and BTB domain containing 16). [provided by Alliance of Genome Resources, Apr 2022]

Zbtb16 Products (3)

mRNA Protein Name
NM_001033324.3 NP_001028496.1 zinc finger and BTB domain-containing protein 16
NM_001364543.1 NP_001351472.1 zinc finger and BTB domain-containing protein 16
NM_001410497.1 NP_001397426.1 zinc finger and BTB domain-containing protein 16

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10207085 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
10835630 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
10835630 MGI
acts upstream of or within embryonic hindlimb morphogenesis IMP
IMP: Inferred from mutant phenotype
10835630 MGI
acts upstream of or within embryonic pattern specification IMP
IMP: Inferred from mutant phenotype
10835630 MGI
acts upstream of or within forelimb morphogenesis IMP
IMP: Inferred from mutant phenotype
10835630 MGI
acts upstream of or within hindlimb morphogenesis IMP
IMP: Inferred from mutant phenotype
10835630 MGI
acts upstream of or within male germ-line stem cell asymmetric division IMP
IMP: Inferred from mutant phenotype
15156142 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
10835630 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
10835630 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
10835630 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
6068186 MGI
Cellular Component GO Annotation Evidence References Source
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
16564520 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15156142 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger and BTB domain-containing protein 16

  • Green's luxoid

  • zinc finger protein 145

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153698 CC-3060 99.7% Unkown
HY-173614 CC-647 Modulator 99.58% Unkown
HY-RS15964 ZBTB16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18204 Zbtb16 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24681 Zbtb16 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zbtb16 NCBI NCBI:7704