PRKD3 - protein kinase D3 Gene

Also Known as EPK2; PKD3; PRKCN; PKC-NU; nPKC-NU

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23683

About PRKD3

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:37,250,502-37,324,833 (from NCBI)

This gene has 10 transcripts (splice variants), 272 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 16.0), testis (RPKM 14.3) and 25 other tissues.

Summary

This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate Cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]

PRKD3 Products (9)

mRNA Protein Name
XM_047443852.1 XP_047299808.1 serine/threonine-protein kinase D3 isoform X1
XM_005264238.4 XP_005264295.1 serine/threonine-protein kinase D3 isoform X2
XM_005264237.5 XP_005264294.1 serine/threonine-protein kinase D3 isoform X1
XM_017003744.3 XP_016859233.1 serine/threonine-protein kinase D3 isoform X4
XM_047443856.1 XP_047299812.1 serine/threonine-protein kinase D3 isoform X5
NM_005813.6 NP_005804.1 serine/threonine-protein kinase D3
XM_047443855.1 XP_047299811.1 serine/threonine-protein kinase D3 isoform X4
XM_047443854.1 XP_047299810.1 serine/threonine-protein kinase D3 isoform X3
XM_047443853.1 XP_047299809.1 serine/threonine-protein kinase D3 isoform X1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables kinase activity IDA
IDA: Inferred from direct assay
22228765 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17196367 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKD3 Protein Structure

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (156 - 205)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (272 - 321)

PH

PH: PH domain (418 - 506)

Pkinase

Pkinase: Protein kinase domain (580 - 832)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 890 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase D3

  • protein kinase C nu type

  • protein kinase EPK2

PRKD3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRKD3 O94806 VAMP2 Homo sapiens P63027
Pull Down
17196367
Intra
PRKD3 O94806 VAMP2 Homo sapiens P63027
Confocal
17196367
Intra
PRKD3 O94806 VAMP2 Homo sapiens P63027
Y2H
17196367
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRKD3 Proteins

Cat. No. Product Name Accession Purity
HY-P73699 PRKD3/nPKC nu Protein, Human (Active, sf9, GST) O94806 (S2-P890) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Conventional Lipoma

  • Classic Type Lipoma
Breast Cancer

  • Breast Carcinoma

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Male Breast Cancer

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11148 PRKD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11149 Prkd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11150 Prkd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PRKD3 VGNC VGNC:44988
Mus musculus PRKD3 MGD MGI:1922542
Bos taurus PRKD3 VGNC VGNC:33338
Rattus norvegicus PRKD3 RGD RGD:1310236
Macaca mulatta PRKD3 VGNC VGNC:76415
Felis catus PRKD3 VGNC VGNC:69066
Others PRKD3 NCBI