FLRT3 - fibronectin leucine rich transmembrane protein 3 Gene

Also Known as HH21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23767

About FLRT3

Cytogenetic location: 20p12.1 Genomic coordinates (GRCh38): 20:14,322,985-14,337,612 (from NCBI)

This gene has 3 transcripts (splice variants), 200 orthologues, 22 paralogues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 12.2), lung (RPKM 9.3) and 16 other tissues.

Summary

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2010]

FLRT3 Products (2)

mRNA Protein Name
NM_013281.4 NP_037413.1 leucine-rich repeat transmembrane protein FLRT3 precursor
NM_198391.3 NP_938205.1 leucine-rich repeat transmembrane protein FLRT3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26235030 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
26235030 GOA
Biological Process GO Annotation Evidence References Source
involved in cell-cell adhesion via plasma-membrane adhesion molecules IDA
IDA: Inferred from direct assay
26235030 GOA
involved in neuron projection extension IMP
IMP: Inferred from mutant phenotype
14706654 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
14706654 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FLRT3 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (106 - 166)

LRR_8

LRR_8: Leucine rich repeat (177 - 237)

LRR_8

LRR_8: Leucine rich repeat (247 - 305)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 649 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat transmembrane protein FLRT3

  • fibronectin-like domain-containing leucine-rich transmembrane protein 3

FLRT3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FLRT3 Q9NZU0 ADGRL3 Homo sapiens Q9HAR2
BLI
26235030
Intra
FLRT3 Q9NZU0 ADGRL3 Homo sapiens Q9HAR2
GMS
26235030
Intra
FLRT3 Q9NZU0 ADGRL3 Homo sapiens Q9HAR2
X-Ray Diffraction
26235030
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FLRT3 Proteins

Cat. No. Product Name Accession Purity
HY-P70924 FLRT3 Protein, Human (HEK293, His) Q9NZU0 (K29-P528) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hypogonadotropic Hypogonadism 21 With Or Without Anosmia

  • HH21

  • Hypogonadotropic Hypogonadism 21 With Anosmia

  • Hypogonadotropic Hypogonadism 21 With Anosmia, Susceptibility To

  • Hypogonadism, Hypogonadotropic, Type 21 With/Without Anosmia
Kallmann Syndrome

  • Hypogonadism With Anosmia

  • Kallman'S Syndrome

  • Anosmic Hypogonadism

  • Anosmic Idiopathic Hypogonadotropic Hypogonadism

  • Hypogonadotropic Hypogonadism And Anosmia

  • Hypogonadotropic Hypogonadism-Anosmia Syndrome

  • Olfacto-Genital Pathological Sequence

  • Familial Hypogonadism With Anosmia

  • Kallman Syndrome

  • Dysplasia Olfactogenitalis Of De Morsier

  • Kallmann'S Syndrome

  • Congenital Hypogonadotropic Hypogonadism With Anosmia
Hypogonadotropic Hypogonadism

  • Klinefelter Syndrome

  • Klinefelter'S Syndrome

  • Xxy Syndrome

  • Xxy Trisomy

  • Hypogonadotropism

  • 47, Xxy

  • Congenital Idiopathic Hypogonadotropic Hypogonadism

  • Isolated Congenital Gonadotropin Deficiency

  • 47,Xxy Syndrome

  • 47, Xxy Syndrome

  • Klinefelters Syndrome

  • Hypogonadism

  • Klinefelter Syndrome In Males

  • Klinefelter Syndrome, Unspecified

  • Klinefelter Syndrome Karyotype 47, Xxy
Hypogonadism
Ectodermal Dysplasia 4, Hair/Nail Type

  • Pure Hair And Nail Ectodermal Dysplasia

  • ECTD4

  • Ectodermal Dysplasia, Pure Hair-Nail Type

  • Ectodermal Dysplasia, 'Pure' Hair/Nail Type

  • Hned

  • Hair-Nail Ectodermal Dysplasia

  • Phned

  • Ectodermal Dysplasia Pure Hair-Nail Type

  • Ectodermal Dysplasia, 'Pure' Hair-Nail Type

  • Dysplasia, Ectodermal, Type 4, Hair/Nail
Sensorineural Hearing Loss

  • Sensory Hearing Loss

  • Sensorineural Deafness

  • Sensorineural Hearing Loss Disorder

  • Hearing Loss, Sensorineural

  • Central Hearing Loss

  • High Frequency Deafness

  • High Frequency Hearing Loss

  • High-Frequency Hearing Loss

  • Perceptive Deafness

  • Perceptive Hearing Loss

  • Perceptive Hearing Loss Or Deafness

  • Hearing Loss Sensorineural

  • Deafness Sensorineural

  • Hearing Loss High-Frequency

  • Hearing Loss, Central

  • Hearing Loss, High-Frequency
Renal Hypodysplasia/Aplasia 1

  • Renal Agenesis

  • Renal Adysplasia

  • Renal Aplasia

  • RHDA1

  • Hereditary Renal Aplasia

  • Hra

  • Hereditary Urogenital Adysplasia

  • Hypodysplasia/Aplasia, Renal, Type 1

  • Congenital Absence Of Kidneys Syndrome

  • Congenital Absence Of Kidney

  • Aplastic Kidney
Cryptorchidism, Unilateral Or Bilateral

  • Cryptorchidism

  • Undescended Testicle

  • Undescended Testis

  • Cryptorchism

  • Undescended Testicles

  • CRYPTO

  • Impaired Testicular Descent

  • Cryptosporidiosis

  • Retained Testis

  • Unilateral Cryptorchidism

  • Unilateral Undescended Testis

  • Nondescent Unilateral Testicle

  • Unilateral Cryptorchism

  • Ectopic Testis, Unilateral

  • Bilateral Cryptorchidism

  • Bilateral Cryptorchism

  • Bilateral Nondescent Testicle

  • Bilateral Undescended Testes

  • Bilateral Ectopic Testes
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04986 FLRT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20409 Flrt3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26918 Flrt3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FLRT3 VGNC VGNC:29040
Felis catus FLRT3 VGNC VGNC:82430
Rattus norvegicus FLRT3 RGD RGD:1566005
Canis familiaris FLRT3 VGNC VGNC:40906
Mus musculus FLRT3 MGD MGI:1918686
Macaca mulatta FLRT3 VGNC VGNC:72677
Others FLRT3 NCBI