Akap5 - A kinase (PRKA) anchor protein 5 Gene

Also Known as P150; Gm258; AKAP-5; AKAP150; AKAP 150; 3526401B18Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 238276

Summary

Enables Adenylate Cyclase binding activity. Involved in clustering of voltage-gated calcium channels; clustering of voltage-gated potassium channels; and receptor clustering. Acts upstream of or within amylase secretion. Located in Cytoskeleton and plasma membrane. Is expressed in brain. Orthologous to human AKAP5 (A-kinase anchoring protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Akap5 Products (1)

mRNA	Protein	Name
NM_001101471.1	NP_001094941.1	A-kinase anchor protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables adenylate cyclase binding	IPI IPI: Inferred from physical interaction	20164376	MGI
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	11943807	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17110924	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within amylase secretion	IMP IMP: Inferred from mutant phenotype	20164376	MGI
acts upstream of or within cellular response to calcium ion	IMP IMP: Inferred from mutant phenotype	23259949	MGI
acts upstream of or within cellular response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	23259949	MGI
involved in clustering of voltage-gated calcium channels	IMP IMP: Inferred from mutant phenotype	27693258	MGI
involved in clustering of voltage-gated potassium channels	IDA IDA: Inferred from direct assay	27693258	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	20164376	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	23259949	MGI
involved in postsynaptic neurotransmitter receptor cycle	IMP IMP: Inferred from mutant phenotype	22623657	MGI
involved in receptor clustering	IDA IDA: Inferred from direct assay	27693258	MGI
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	22623657	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoskeleton	IDA IDA: Inferred from direct assay	20164376	MGI
located in dendrite	IDA IDA: Inferred from direct assay	17110924	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	20164376	MGI
is active in postsynaptic recycling endosome	IDA IDA: Inferred from direct assay	22623657	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
A-kinase anchor protein 5	A-kinase anchor protein 150 kDa cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00520	AKAP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21476	Akap5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27994	Akap5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Akap5	NCBI	NCBI:9495