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Grem1 - gremlin 1, DAN family BMP antagonist Gene

Also Known as ld; Drm; Grem; Cktsf1b1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 23892

Summary

Enables receptor ligand activity; transmembrane receptor protein tyrosine kinase activator activity; and vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including cell migration involved in sprouting angiogenesis; nephron epithelium morphogenesis; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of branching involved in ureteric bud morphogenesis; and regulation of signal transduction. Located in extracellular space. Colocalizes with cell surface. Is expressed in several structures, including embryo mesenchyme; limb bud; neural ectoderm; sensory organ; and skeleton. Orthologous to human GREM1 (gremlin 1, Dan family BMP antagonist). [provided by Alliance of Genome Resources, Apr 2022]

Grem1 Products (2)

mRNA	Protein	Name
NM_011824.4	NP_035954.1	gremlin-1 precursor
NM_011824.4	NP_035954.1	gremlin-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables receptor ligand activity	IPI IPI: Inferred from physical interaction	20660291	MGI
enables transmembrane receptor protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	20660291	MGI
enables vascular endothelial growth factor receptor 2 binding	IPI IPI: Inferred from physical interaction	20660291	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within angiogenesis	IDA IDA: Inferred from direct assay	18505784	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	15198975	MGI
involved in cardiac muscle cell differentiation	IDA IDA: Inferred from direct assay	18545679	MGI
involved in cardiac muscle cell myoblast differentiation	IDA IDA: Inferred from direct assay	18545679	MGI
involved in cell migration involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	17077323	MGI
acts upstream of or within cell-cell signaling	IMP IMP: Inferred from mutant phenotype	15201225	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	12808456	MGI
involved in endothelial cell migration	IDA IDA: Inferred from direct assay	17077323	MGI
involved in mesenchymal to epithelial transition involved in metanephros morphogenesis	IDA IDA: Inferred from direct assay	17522159	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	17522159	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17522159	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17522159	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	18505784	MGI
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	17077323	MGI
acts upstream of or within positive regulation of branching involved in ureteric bud morphogenesis	IDA IDA: Inferred from direct assay	21281623	MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis	IDA IDA: Inferred from direct assay	17522159	MGI
acts upstream of or within positive regulation of branching involved in ureteric bud morphogenesis	IGI IGI: Inferred from genetic interaction	17522159	MGI
acts upstream of or within positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	18505784	MGI
involved in positive regulation of peptidyl-tyrosine autophosphorylation	IDA IDA: Inferred from direct assay	20660291	MGI
involved in positive regulation of protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	17077323	MGI
involved in positive regulation of receptor internalization	IDA IDA: Inferred from direct assay	20660291	MGI
involved in positive regulation of signaling receptor activity	IDA IDA: Inferred from direct assay	20660291	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12135612	MGI
acts upstream of or within proximal/distal pattern formation	IMP IMP: Inferred from mutant phenotype	12808456	MGI
involved in regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	17077323	MGI
NOT involved in regulation of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	12135612	MGI
involved in signal transduction	IDA IDA: Inferred from direct assay	20660291	MGI
NOT involved in signal transduction by p53 class mediator	IGI IGI: Inferred from genetic interaction	12135612	MGI
involved in ureteric bud formation	IDA IDA: Inferred from direct assay	17522159	MGI

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with cell surface	IDA IDA: Inferred from direct assay	17077323	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	17077323	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
gremlin-1	cysteine knot superfamily 1, BMP antagonist 1 down-regulated in Mos-transformed cells protein down-regulated in v-mos-transformed cells

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112056	DIM-C-pPhCO2Me		99.47%	Unkown
HY-RS05784	GREM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17341	Grem1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23796	Grem1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990426	Anti-GREM1/Gremlin Antibody		98.59%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grem1	NCBI	NCBI:26585