Ago2 - argonaute RISC catalytic subunit 2 Gene

Also Known as Eif2c2; Gerp95; Gm10365; mKIAA4215; 1110029L17Rik; 2310051F07Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 239528

Summary

Enables endoribonuclease activity; mRNA binding activity; and miRNA binding activity. Involved in regulation of gene expression. Acts upstream of or within RNA metabolic process; positive regulation of gene expression; and post-embryonic development. Located in several cellular components, including P-body; cytosol; and dendrite. Part of RISC complex and RISC-loading complex. Is expressed in several structures, including central nervous system; early embryo; lung; sensory organ; and tooth. Orthologous to human AGO2 (argonaute RISC catalytic component 2). [provided by Alliance of Genome Resources, Apr 2022]

Ago2 Products (1)

mRNA	Protein	Name
NM_153178.5	NP_694818.3	protein argonaute-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	19536157	MGI
enables RNA endonuclease activity	IDA IDA: Inferred from direct assay	20424607	MGI
enables mRNA binding	IDA IDA: Inferred from direct assay	20975942	MGI
enables miRNA binding	IDA IDA: Inferred from direct assay	23185045	MGI
enables miRNA binding	IMP IMP: Inferred from mutant phenotype	22503104	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12526743	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within miRNA metabolic process	IDA IDA: Inferred from direct assay	22053081	MGI
acts upstream of or within miRNA processing	IMP IMP: Inferred from mutant phenotype	20424607	MGI
involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	16357216	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22053081	MGI
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP IMP: Inferred from mutant phenotype	19716330	MGI
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IMP IMP: Inferred from mutant phenotype	19716330	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	20424607	MGI
involved in pre-miRNA processing	IDA IDA: Inferred from direct assay	16357216	MGI
involved in regulatory ncRNA-mediated gene silencing	IMP IMP: Inferred from mutant phenotype	19716330	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	19898466	MGI
part of RISC complex	IDA IDA: Inferred from direct assay	16357216	MGI
part of RISC-loading complex	IDA IDA: Inferred from direct assay	16357216	MGI
part of RISC-loading complex	IPI IPI: Inferred from physical interaction	20211135	MGI
located in cytosol	IDA IDA: Inferred from direct assay	22053081	MGI
located in dendrite	IDA IDA: Inferred from direct assay	22022532	MGI
located in nucleus	IDA IDA: Inferred from direct assay	22053081	MGI
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	24427314	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein argonaute-2	Piwi/Argonaute family protein meIF2C2 argonaute 2 argonaute RISC catalytic component 2 eukaryotic translation initiation factor 2C, 2

Recombinant Ago2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74423	AGO2/Argonaute-2 Protein, Mouse (sf9, His)	Q8CJG0 (M1-A860)	≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119024	BCI-137		99.84%	Unkown
HY-RS00453	AGO2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17683	Ago2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24144	Ago2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ago2	NCBI	NCBI:27161