AGO2 - argonaute RISC catalytic component 2 Gene

Homo sapiens

Also known as PPD; Q10; CASC7; EIF2C2; LESKRES; LINC00980

Gene ID: 27161 | Gene type: protein coding

About AGO2

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:140,520,156-140,642,313 (from NCBI)

This gene has 10 transcripts (splice variants), 211 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in skin (RPKM 3.3), ovary (RPKM 3.3) and 25 other tissues.

Summary

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

AGO2 Products(2)

mRNA	Protein	Name
NM_001164623.3	NP_001158095.1	protein argonaute-2 isoform 2
NM_012154.5	NP_036286.2	protein argonaute-2 isoform 1

AGO2 Protein Structure

ArgoL1

PAZ

Piwi

0
200
400
600
800
859 a.a.

Protein Preferred Names

Protein Names

protein argonaute-2

PAZ Piwi domain protein

Recombinant AGO2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72835	AGO2/Argonaute-2 Protein, Human (sf9, His)	Q9UKV8 (M1-A859)	≥95%

Related Diseases

Diseases

Alias

Lessel-Kreienkamp Syndrome

LESKRES

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Eunuchism

Patau Syndrome

Trisomy 13	Complete Trisomy 13 Syndrome
Trisomy 13 Syndrome	D1 Trisomy
Patau'S Syndrome	Complete Trisomy 13
Chromosome 13, Trisomy 13 Complete	D Trisomy Syndrome
Bartholin-Patau Syndrome	Chromosome 13 Duplication
D1 Trisomy Syndrome	D>1< Trisomy Syndrome
Patau	Chromosome 13 Trisomy
Abnormal Autosomes 13

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
X-Linked Intellectual Disability And Macroorchidism	Frax Syndrome
Symptomatic Form Of Fragile X Syndrome In Female Carriers	Fragile-X Syndrome
Fraxe Syndrome

Orofaciodigital Syndrome Viii

Edwards Syndrome	Trisomy 18
Complete Trisomy 18 Syndrome	OFD8
Orofaciodigital Syndrome 8	Trisomy 18 Syndrome
Oral-Facial-Digital Syndrome With Hypoplastic Epiglottis	E3 Trisomy
Oral-Facial-Digital Syndrome Type 8	Orofaciodigital Syndrome Type 8
Ofds Viii	Oral-Facial-Digital Syndrome, Type Viii
Ofd Syndrome 8	Ofds 8
Oral Facial Digital Syndrome 8	Oral Facial Digital Syndrome Type 8
18 Trisomy	Chromosome 18 Trisomy
Trisomy 16-18	Trisomy E
Trisomy E Syndrome	Chromosome 18 Duplication
Oral-Facial-Digital Syndrome, Edwards Type	Orofaciodigital Syndrome, Edwards Type
Chromosome 18, Trisomy	Cleft Lip/Palate With Abnormal Thumbs And Microcephaly
Trisomy 18 Chromosome	Abnormal Autosomes 18

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Cervical Non-Keratinizing Squamous Cell Carcinoma

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119024	BCI-137		≥99.0%	Unkown
HY-RS00453	AGO2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AGO2	RGD	RGD:621255
Mus musculus	AGO2	MGD	MGI:2446632
Felis catus	AGO2	VGNC	VGNC:81639
Canis familiaris	AGO2	VGNC	VGNC:37707
Bos taurus	AGO2	VGNC	VGNC:50167
Macaca mulatta	AGO2	VGNC	VGNC:81347
Others	AGO2	NCBI

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