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Cib1 - calcium and integrin binding 1 (calmyrin) Gene

Also Known as Kip; Cibkip; Prkdcip

Species: Mus musculus

Gene Type: protein coding

Gene ID: 23991

Summary

Enables protein-membrane adaptor activity and transmembrane transporter binding activity. Involved in several processes, including negative regulation of megakaryocyte differentiation; regulation of intracellular signal transduction; and regulation of protein phosphorylation. Located in cytoplasm and sarcolemma. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human CIB1 (calcium and Integrin binding 1). [provided by Alliance of Genome Resources, Apr 2022]

Cib1 Products (3)

mRNA	Protein	Name
NM_001291275.1	NP_001278204.1	calcium and integrin-binding protein 1 isoform 2
NM_001291276.1	NP_001278205.1	calcium and integrin-binding protein 1 isoform 3
NM_011870.5	NP_036000.1	calcium and integrin-binding protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20639889	MGI
enables protein-membrane adaptor activity	IMP IMP: Inferred from mutant phenotype	20639889	MGI
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	20639889	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	17975111	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16982698	MGI
involved in negative regulation of megakaryocyte differentiation	IMP IMP: Inferred from mutant phenotype	22128142	MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	22128142	MGI
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22128142	MGI
involved in platelet formation	IMP IMP: Inferred from mutant phenotype	22128142	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	17975111	MGI
involved in positive regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	20639889	MGI
involved in positive regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	17975111	MGI
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	16982698	MGI
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	22128142	MGI
involved in positive regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	17975111	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17975111	MGI
involved in positive regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	22128142	MGI
involved in positive regulation of male germ cell proliferation	IMP IMP: Inferred from mutant phenotype	16982698	MGI
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	20639889	MGI
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	17975111	MGI
involved in positive regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	17975111	MGI
involved in response to ischemia	IDA IDA: Inferred from direct assay	17975111	MGI
involved in spermatid development	IMP IMP: Inferred from mutant phenotype	16982698	MGI
involved in thrombopoietin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	22128142	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20639889	MGI
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	10366599	MGI
located in membrane	IDA IDA: Inferred from direct assay	10366599	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	20639889	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
calcium and integrin-binding protein 1	CIB DNA-PKcs-interacting protein calcium and integrin binding, protein kinase interacting protein calmyrin kinase-interacting protein protein kinase, DNA activated, catalytic polypeptide interacting protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162558	NCGC00351170	Inhibitor	99.05%	Unkown
HY-RS02706	CIB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19584	Cib1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26081	Cib1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cib1	NCBI	NCBI:10519