Rbck1 - RanBP-type and C3HC4-type zinc finger containing 1 Gene

Also Known as UIP28; HOIL-1; HOIL-1L; Ubce7ip3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 24105

Summary

Predicted to enable several functions, including protein kinase C binding activity; protein sequestering activity; and ubiquitin binding activity. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NIK/NF-kappaB signaling; and positive regulation of apoptotic process. Acts upstream of or within negative regulation of necroptotic process and positive regulation of extrinsic apoptotic signaling pathway. Predicted to be part of LUBAC complex. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in glycogen storage disease. Orthologous to human RBCK1 (RANBP2-type and C3HC4-type zinc finger containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Rbck1 Products (3)

mRNA Protein Name
NM_001083921.1 NP_001077390.1 ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform a
NM_001355282.1 NP_001342211.1 ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform b
NM_019705.3 NP_062679.2 ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20956555 MGI
enables ubiquitin ligase activator activity IDA
IDA: Inferred from direct assay
34755089 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of necroptotic process IGI
IGI: Inferred from genetic interaction
22089168 MGI
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19136968 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
19136968 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
19136968 MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
19136968 MGI
involved in protein polyubiquitination IMP
IMP: Inferred from mutant phenotype
34755089 MGI
Cellular Component GO Annotation Evidence References Source
part of LUBAC complex IDA
IDA: Inferred from direct assay
19136968 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ranBP-type and C3HC4-type zinc finger-containing protein 1

  • RING-type E3 ubiquitin transferase HOIL-1

  • heme-oxidized IRP2 ubiquitin ligase 1 homolog

  • novel zinc finger, C3HC4 type (RING finger) protein

  • ubcM4-interacting protein 28

  • ubiquitin-conjugating enzyme 7-interacting protein 3

Rbck1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Rbck1 Q9WUB0 Rnf31 Mus musculus Q924T7
Anti Bait CoIP
21455180
Intra
Rbck1 Q9WUB0 Rnf31 Mus musculus Q924T7
GMS
21455180
Intra
Rbck1 Q9WUB0 Rnf31 Mus musculus Q924T7
GMS
23942237
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11722 RBCK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20479 Rbck1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26987 Rbck1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rbck1 NCBI NCBI:10616