Zeb2 - zinc finger E-box binding homeobox 2 Gene

Also Known as SIP1; Zfx1b; Zfhx1b; Zfxh1b; 9130203F04Rik; D130016B08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 24136

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and R-SMAD binding activity. Involved in several processes, including melanocyte migration; positive regulation of cell differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including nervous system development; neural crest cell migration; and positive regulation of signal transduction. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Mowat-Wilson syndrome and T-cell adult acute lymphocytic leukemia. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Zeb2 Products (6)

mRNA Protein Name
NM_001289521.2 NP_001276450.1 zinc finger E-box-binding homeobox 2
NM_001355288.2 NP_001342217.1 zinc finger E-box-binding homeobox 2
NM_001355289.2 NP_001342218.1 zinc finger E-box-binding homeobox 2
NM_001355290.2 NP_001342219.1 zinc finger E-box-binding homeobox 2
NM_001355291.2 NP_001342220.1 zinc finger E-box-binding homeobox 2
NM_015753.5 NP_056568.2 zinc finger E-box-binding homeobox 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
25741725 MGI
enables R-SMAD binding IDA
IDA: Inferred from direct assay
16115198 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell proliferation in forebrain IMP
IMP: Inferred from mutant phenotype
17644613 MGI
acts upstream of or within central nervous system development IGI
IGI: Inferred from genetic interaction
16598713 MGI
acts upstream of or within collateral sprouting IMP
IMP: Inferred from mutant phenotype
25741725 MGI
acts upstream of or within corpus callosum morphogenesis IMP
IMP: Inferred from mutant phenotype
25741725 MGI
acts upstream of or within corticospinal tract morphogenesis IMP
IMP: Inferred from mutant phenotype
25741725 MGI
involved in developmental pigmentation IMP
IMP: Inferred from mutant phenotype
24769727 MGI
acts upstream of or within embryonic morphogenesis IGI
IGI: Inferred from genetic interaction
16598713 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
17644613 MGI
acts upstream of or within mammillary axonal complex development IMP
IMP: Inferred from mutant phenotype
25741725 MGI
involved in melanocyte migration IMP
IMP: Inferred from mutant phenotype
24769727 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24769727 MGI
acts upstream of or within neural crest cell migration IMP
IMP: Inferred from mutant phenotype
12522767 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
16598713 MGI
acts upstream of or within positive regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
17644613 MGI
acts upstream of or within positive regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
17644613 MGI
acts upstream of or within positive regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
25741725 MGI
involved in positive regulation of lens fiber cell differentiation IMP
IMP: Inferred from mutant phenotype
16162653 MGI
involved in positive regulation of melanocyte differentiation IMP
IMP: Inferred from mutant phenotype
24769727 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
25741725 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24769727 MGI
involved in regulation of melanosome organization IMP
IMP: Inferred from mutant phenotype
24769727 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
16157277 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
24769727 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger E-box-binding homeobox 2

  • smad-interacting protein 1

  • zinc finger homeobox protein 1b

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-131445 RJW100 Activator 99.93% Unkown
HY-173557 PRMT7-IN-2 98.26% Unkown
HY-RS17821 Zeb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16026 ZEB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24289 Zeb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zeb2 NCBI NCBI:9839