Acr - acrosin Gene

Also Known as Acro

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24163

Summary

Predicted to enable amidase activity; monosaccharide binding activity; and serine-type endopeptidase activity. Involved in acrosome matrix dispersal; penetration of zona pellucida; and response to steroid hormone. Located in Golgi-associated vesicle and acrosomal vesicle. Orthologous to human ACR (acrosin). [provided by Alliance of Genome Resources, Apr 2022]

Acr Products (1)

mRNA Protein Name
NM_012490.2 NP_036622.2 acrosin precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in acrosome matrix dispersal IMP
IMP: Inferred from mutant phenotype
28859281 RGD
involved in penetration of zona pellucida IMP
IMP: Inferred from mutant phenotype
28859281 RGD
involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
28859281 RGD
involved in response to steroid hormone IDA
IDA: Inferred from direct assay
9838878 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi-associated vesicle IDA
IDA: Inferred from direct assay
8601690 RGD
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
8601690 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acrosin

  • acrosin prepropeptide

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-111210 Pridopidine hydrochloride Antagonist / Phase 3
HY-19845 Ordopidine Antagonist / Phase 1
HY-19845A Ordopidine hydrochloride Modulator / Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10684 Pridopidine Antagonist 99.85% Yes
HY-129126 NC9 Inhibitor 99.98% Unkown
HY-RS00193 ACR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17573 Acr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24033 Acr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acr NCBI NCBI:49