Adra2c - adrenoceptor alpha 2C Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24175

Summary

Predicted to enable several functions, including alpha-2A Adrenergic Receptor binding activity; alpha2-adrenergic receptor activity; and protein dimerization activity. Involved in several processes, including negative regulation of uterine smooth muscle contraction; positive regulation of vasoconstriction; and regulation of sensory perception of pain. Located in axon terminus and neuronal cell body. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human ADRA2C (adrenoceptor alpha 2C). [provided by Alliance of Genome Resources, Apr 2022]

Adra2c Products (1)

mRNA Protein Name
NM_138506.2 NP_612515.2 alpha-2C adrenergic receptor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in female pregnancy IMP
IMP: Inferred from mutant phenotype
19450576 RGD
involved in negative regulation of uterine smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
17664026 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
20862454 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
15207357 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
12379250 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
9552127 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
9552127 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12379250 RGD
is active in postsynaptic density membrane EXP
EXP: Inferred from Experiment
9552127 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
9552127 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
9552127 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-2C adrenergic receptor

  • Adrenergic alpha2C- receptor class I

  • Adrenergic, alpha2C-, receptor class I

  • adrenergic receptor, alpha 2c

  • adrenergic, alpha-2C-, receptor

  • alpha-2 adrenergic receptor subtype C4

  • alpha-2C adrenoceptor

  • alpha-2C adrenoreceptor

  • alpha-2CAR

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00413 ADRA2C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20136 Adra2c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26639 Adra2c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adra2c NCBI NCBI:152