Atp7b - ATPase copper transporting beta Gene

Also Known as Wd; Hts; PINA

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24218

Summary

Enables copper ion binding activity; copper ion transmembrane transporter activity; and zinc ion binding activity. Involved in several processes, including cellular response to metal ion; copper ion export; and lactation. Located in several cellular components, including basolateral plasma membrane; bicellular tight junction; and trans-Golgi network. Used to study Wilson disease; hepatitis; hepatocellular carcinoma; liver carcinoma; and renal adenoma. Human ortholog(s) of this gene implicated in Wilson disease. Orthologous to human ATP7B (ATPase copper transporting beta). [provided by Alliance of Genome Resources, Apr 2022]

Atp7b Products (1)

mRNA Protein Name
NM_012511.2 NP_036643.2 copper-transporting ATPase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables copper ion binding IDA
IDA: Inferred from direct assay
14732483 RGD
enables copper ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
9920665 RGD
enables zinc ion binding IDA
IDA: Inferred from direct assay
14732483 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to copper ion IEP
IEP: Inferred from expression pattern
24614235 RGD
involved in cellular response to copper ion IMP
IMP: Inferred from mutant phenotype
24614235 RGD
involved in cellular response to manganese ion IEP
IEP: Inferred from expression pattern
24614235 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
9920665 RGD
involved in copper ion export IMP
IMP: Inferred from mutant phenotype
24614235 RGD
involved in lactation IEP
IEP: Inferred from expression pattern
16741141 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
9920665 RGD
involved in response to copper ion IEP
IEP: Inferred from expression pattern
15591161 RGD
involved in response to prolactin IEP
IEP: Inferred from expression pattern
16741141 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
12840169 RGD
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
15994426 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
24614235 RGD
located in bicellular tight junction IDA
IDA: Inferred from direct assay
18395099 RGD
located in late endosome IDA
IDA: Inferred from direct assay
16741141 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
24614235 RGD
located in tight junction IDA
IDA: Inferred from direct assay
18395099 RGD
located in trans-Golgi network IDA
IDA: Inferred from direct assay
15994426 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

copper-transporting ATPase 2

  • ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease)

  • PINA gene, promoter

  • copper pump 2

  • pineal night-specific ATPase

  • wilson disease-associated protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01236 ATP7B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W783351 CS790AM / Unkown
HY-RS17601 Atp7b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24061 Atp7b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp7b NCBI NCBI:540