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Cebpa - CCAAT/enhancer binding protein alpha Gene

Also Known as DBPCEP

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24252

Summary

This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. The use of alternative in-frame non-AUG (CUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the CUG and the first AUG start codons. [provided by RefSeq, Aug 2014]

Cebpa Products (4)

mRNA	Protein	Name
NM_001287577.1	NP_001274506.1	CCAAT/enhancer-binding protein alpha isoform c
NM_001287578.1	NP_001274507.1	CCAAT/enhancer-binding protein alpha isoform d
NM_001287579.1	NP_001274508.1	CCAAT/enhancer-binding protein alpha isoform b
NM_012524.3	NP_036656.1	CCAAT/enhancer-binding protein alpha isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	1377818	RGD
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8572170	RGD
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	20176812	RGD
enables HMG box domain binding	IPI IPI: Inferred from physical interaction	16582099	RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8572170	RGD
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	23639777	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	1377818	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	11356826	RGD
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	8367486	RGD
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	2171780	RGD
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	8367486	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	16172914	RGD
contributes to sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8657121	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20176812	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in acute-phase response	IEP IEP: Inferred from expression pattern	16172914	RGD
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	17047332	RGD
involved in cell differentiation	IEP IEP: Inferred from expression pattern	16735515	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	1377818	RGD
involved in fat cell differentiation	IDA IDA: Inferred from direct assay	11672531	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	16172914	RGD
involved in memory	IEP IEP: Inferred from expression pattern	17512093	RGD
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11672531	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11672531	RGD
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8657121	RGD
involved in osteoblast development	IEP IEP: Inferred from expression pattern	1377818	RGD
involved in positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	11731483	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8572170	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12554749	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	12753899	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	16856317	RGD
involved in response to phenylpropanoid	IEP IEP: Inferred from expression pattern	23238999	RGD
involved in response to vitamin B2	IEP IEP: Inferred from expression pattern	16856317	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of CHOP-C/EBP complex	IPI IPI: Inferred from physical interaction	8657121	RGD
part of Rb-E2F complex	IDA IDA: Inferred from direct assay	16172914	RGD
located in nuclear matrix	IDA IDA: Inferred from direct assay	16172914	RGD
located in nucleolus	IDA IDA: Inferred from direct assay	20075868	RGD
located in nucleus	IDA IDA: Inferred from direct assay	8657121	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	11356826	RGD
part of transcription regulator complex	IDA IDA: Inferred from direct assay	12554749	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
CCAAT/enhancer-binding protein alpha	C/EBP alpha CAAT/enhancer-binding protein, DNA-binding protein CCAAT/enhancer binding protein (C/EBP), alpha

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132607A	MTL-CEBPA sodium		91.62%	Phase 2
HY-132607	MTL-CEBPA		95.52%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-168483	FTO-IN-13		/	Unkown
HY-179267	FTO-IN-16		/	Unkown
HY-RS02445	CEBPA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-177371	CEBPA-51 saRNA		/	Unkown
HY-RS18653	Cebpa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25139	Cebpa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cebpa	NCBI	NCBI:1050