Chga - chromogranin A Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24258

Summary

Involved in several processes, including adenylate cyclase-activating Adrenergic Receptor signaling pathway involved in cardiac muscle relaxation; positive regulation of signal transduction; and regulation of blood circulation. Located in chromaffin granule; extracellular space; and neuronal dense core vesicle. Biomarker of hypertension. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypertension; and prostate Cancer. Orthologous to human CHGA (chromogranin A). [provided by Alliance of Genome Resources, Apr 2022]

Chga Products (1)

mRNA Protein Name
NM_021655.2 NP_067687.2 chromogranin-A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12388744 RGD
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation IDA
IDA: Inferred from direct assay
22459152 RGD
involved in ovulation cycle IEP
IEP: Inferred from expression pattern
12873792 RGD
involved in positive regulation of cAMP/PKA signal transduction IDA
IDA: Inferred from direct assay
22459152 RGD
involved in positive regulation of cardiac muscle contraction IDA
IDA: Inferred from direct assay
22459152 RGD
involved in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11257446 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
22459152 RGD
involved in positive regulation of relaxation of cardiac muscle IDA
IDA: Inferred from direct assay
22459152 RGD
involved in positive regulation of vasoconstriction IDA
IDA: Inferred from direct assay
15544843 RGD
involved in regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
22459152 RGD
involved in regulation of the force of heart contraction IDA
IDA: Inferred from direct assay
22459152 RGD
Cellular Component GO Annotation Evidence References Source
located in chromaffin granule IDA
IDA: Inferred from direct assay
19372204 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
12873792 RGD
located in neuronal dense core vesicle IDA
IDA: Inferred from direct assay
29166604 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
12388744 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chromogranin-A

  • cgA

  • chromogranin A (parathyroid secretory protein 1)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02624 CHGA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18918 Chga Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25408 Chga Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chga NCBI NCBI:1113