Chrm3 - cholinergic receptor, muscarinic 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24260

Summary

Enables several functions, including G protein-coupled acetylcholine receptor activity; G protein-coupled acetylcholine receptor binding activity; and acetylcholine binding activity. Involved in G protein-coupled acetylcholine receptor signaling pathway; negative regulation of heart rate by acetylcholine; and positive regulation of vascular associated smooth muscle contraction. Located in several cellular components, including asymmetric synapse; axon terminus; and dendrite. Is integral component of plasma membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3). [provided by Alliance of Genome Resources, Apr 2022]

Chrm3 Products (1)

mRNA Protein Name
NM_012527.2 NP_036659.2 muscarinic acetylcholine receptor M3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled acetylcholine receptor activity IDA
IDA: Inferred from direct assay
1527051 RGD
enables G protein-coupled acetylcholine receptor binding IDA
IDA: Inferred from direct assay
9316844 RGD
enables acetylcholine binding IDA
IDA: Inferred from direct assay
1527051 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
20461055 RGD
enables quaternary ammonium group binding IDA
IDA: Inferred from direct assay
8075871 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled acetylcholine receptor signaling pathway IDA
IDA: Inferred from direct assay
1527051 RGD
involved in G protein-coupled acetylcholine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15141107 RGD
involved in negative regulation of heart rate by acetylcholine IMP
IMP: Inferred from mutant phenotype
9316844 RGD
involved in positive regulation of vascular associated smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
8428203 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
9316844 RGD
involved in response to acetylcholine IMP
IMP: Inferred from mutant phenotype
8075871 RGD
Cellular Component GO Annotation Evidence References Source
located in asymmetric synapse IDA
IDA: Inferred from direct assay
8182478 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
8182478 RGD
located in dendrite IDA
IDA: Inferred from direct assay
8182478 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
8182478 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
1527051 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
8182478 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
8182478 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

muscarinic acetylcholine receptor M3

  • cholinergic receptor, muscarinic 3, cardiac

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02662 CHRM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19180 Chrm3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25668 Chrm3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrm3 NCBI NCBI:1131