CHRM3 - cholinergic receptor muscarinic 3 Gene

Also Known as HM3; PBS; EGBRS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1131

About CHRM3

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:239,386,568-239,915,450 (from NCBI)

This gene has 12 transcripts (splice variants), 257 orthologues, 25 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 5.0), salivary gland (RPKM 2.4) and 12 other tissues.

Summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as Adenylate Cyclase inhibition, phosphoinositide degeneration, and Potassium Channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]

CHRM3 Products (10)

mRNA	Protein	Name
NM_000740.4	NP_000731.1	muscarinic acetylcholine receptor M3
NM_001347716.2	NP_001334645.1	muscarinic acetylcholine receptor M3
NM_001375978.1	NP_001362907.1	muscarinic acetylcholine receptor M3
NM_001375979.1	NP_001362908.1	muscarinic acetylcholine receptor M3
NM_001375980.1	NP_001362909.1	muscarinic acetylcholine receptor M3
NM_001375981.1	NP_001362910.1	muscarinic acetylcholine receptor M3
NM_001375982.1	NP_001362911.1	muscarinic acetylcholine receptor M3
NM_001375983.1	NP_001362912.1	muscarinic acetylcholine receptor M3
NM_001375984.1	NP_001362913.1	muscarinic acetylcholine receptor M3
NM_001375985.1	NP_001362914.1	muscarinic acetylcholine receptor M3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19575010	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in acetylcholine receptor signaling pathway	IDA IDA: Inferred from direct assay	17478539	GOA
acts upstream of or within calcium-mediated signaling	IDA IDA: Inferred from direct assay	17478539	GOA
acts upstream of or within regulation of monoatomic ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	17478539	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in basal plasma membrane	IDA IDA: Inferred from direct assay	17478539	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21056967	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHRM3 Protein Structure

7tm_1

0
100
200
300
400
500
590 a.a.

Protein Preferred Names	Protein Names
muscarinic acetylcholine receptor M3	acetylcholine receptor, muscarinic 3

CHRM3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CHRM3	P20309	CHRM5	Homo sapiens	P08912	BRET	20398705

Cross: Cross-species interaction Intra: Intraspecies interaction

CHRM3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84170	CHRM3 Antibody (YA3867)	IHC-P, ICC/IF, FC	Human, Mouse, Rabbit
HY-P84170A	CHRM3 Antibody (YA3867)(PBS only)	IHC-P, ICC/IF, FC	Human, Mouse, Rabbit

Related Diseases

Diseases	Alias
Prune Belly Syndrome	Eagle-Barrett Syndrome Abdominal Muscle Deficiency Syndrome PBS Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism Egbrs Eagle-Barret Syndrome Urethral Obstruction Sequence Obrinsky Syndrome Triad Syndrome Obrisnksy Syndrome Euos Early Urethral Obstruction Sequence Renal Dysplasia Or Hydronephrosis, Oligohydramnios And Subsequent Lung Hypoplasia Due To Urethral Obstruction Absence Of Abdominal Muscles With Urinary Tract Abnormality And Cryptorchidism Abdomen Muscle Deficiency Syndrome Abdomen Muscular Deficiency Syndrome Abdominal Muscular Deficiency Syndrome Abdominal Muscle Aplasia Syndrome
Low Compliance Bladder	Overactive Bladder Hyperactivity Of Bladder Hypertonic Bladder Hypertonicity Of Bladder Low Bladder Compliance Oab - [Overactive Bladder]
Sjogren Syndrome	Sicca Syndrome Sjogren'S Syndrome Sjögren Syndrome Sjogren-Gougerot Syndrome Keratoconjunctivitis Sicca Sjögren'S Syndrome Xerodermosteosis Dacryosialoadenopathia Atrophicans Gougerot-Houwer-Sjogren Syndrome Gougerot-Sjogren Syndrome Keratoconjunctivitis Sicca-Xerostomia Secreto-Inhibitor-Xerodermostenosis Primary Sjogren Syndrome Primary Sjogren-Gougerot Syndrome Sjogrens Syndrome Primary Sjogrens Syndrome Dry Eye Syndromes
Cholinergic Urticaria
Aplasia Of Lacrimal And Salivary Glands	ALSG Congenital Absence Of Lacrimal Puncta And Salivary Glands Xerostomia Absence Of Salivary Glands Parotid Aplasia Or Hypoplasia Congenital Absence Of Lacrimal Puncta Or Salivary Glands Alsg - [Aplasia Of Lacrimal Or Salivary Glands]
Urofacial Syndrome 1	Urofacial Syndrome Ochoa Syndrome Hydronephrosis With Peculiar Facial Expression Ufs Inverted Smile And Occult Neuropathic Bladder Partial Facial Palsy With Urinary Abnormalities UFS1 Urofacial Ochoa'S Syndrome Urofacial Syndrome Type 1 Facial Palsy, Partial, With Urinary Abnormalities Hydronephrosis-Inverted Smile Inverted Smile-Neurogenic Bladder Hydronephrosis-Inverted Smile Syndrome Inverted Smile-Neurogenic Bladder Syndrome Partial Facial Palsy Partial With Urinary Abnormalities Urologic Diseases
Physical Urticaria	Symptomatic Dermographism
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Functional Colonic Disease	Colonic Diseases, Functional
Colonic Pseudo-Obstruction	Primary Chronic Pseudo-Obstruction Of Colon
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02662	CHRM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19180	Chrm3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25668	Chrm3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CHRM3	VGNC	VGNC:27320
Canis familiaris	CHRM3	VGNC	VGNC:39233
Mus musculus	CHRM3	MGD	MGI:88398
Felis catus	CHRM3	VGNC	VGNC:60875
Rattus norvegicus	CHRM3	RGD	RGD:2343
Macaca mulatta	CHRM3	VGNC	VGNC:71043
Others	CHRM3	NCBI