2. Gene
  3. CHRM5 - cholinergic receptor muscarinic 5 Gene

CHRM5 - cholinergic receptor muscarinic 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HM5

Gene ID: 1133 | Gene type: protein coding

About CHRM5

Cytogenetic location: 15q14 Genomic coordinates (GRCh38): 15:33,968,497-34,067,458 (from NCBI)

This gene has 3 transcripts (splice variants), 264 orthologues and 25 paralogues. Low expression observed in reference dataset.

Summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as Adenylate Cyclase inhibition, phosphoinositide degeneration, and Potassium Channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]

CHRM5 Products(2)

mRNA Protein Name
NM_001320917.2 NP_001307846.1 muscarinic acetylcholine receptor M5
NM_012125.4 NP_036257.1 muscarinic acetylcholine receptor M5

CHRM5 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (47 - 495)

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  • 532 a.a.
Protein Preferred Names Protein Names

muscarinic acetylcholine receptor M5

acetylcholine receptor, muscarinic 5

Related Diseases

Diseases Alias
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02664 CHRM5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CHRM5 VGNC VGNC:39235
Bos taurus CHRM5 VGNC VGNC:27321
Felis catus CHRM5 VGNC VGNC:60877
Rattus norvegicus CHRM5 RGD RGD:620027
Macaca mulatta CHRM5 VGNC VGNC:71044
Mus musculus CHRM5 MGD MGI:109248