Grin1 - glutamate ionotropic receptor NMDA type subunit 1 Gene

Also Known as NR1; GluN1; NMDAR1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24408

Summary

Enables several functions, including amino acid binding activity; amyloid-beta binding activity; and ligand-gated ion channel activity. Involved in several processes, including positive regulation of dendritic spine maintenance; protein heterotetramerization; and response to fungicide. Located in several cellular components, including dendrite; postsynaptic density; and synaptic cleft. Is integral component of plasma membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Biomarker of cognitive disorder; middle cerebral artery infarction; placental insufficiency; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Grin1 Products (8)

mRNA Protein Name
NM_001270602.1 NP_001257531.1 glutamate receptor ionotropic, NMDA 1 isoform 1b precursor
NM_001270603.1 NP_001257532.1 glutamate receptor ionotropic, NMDA 1 isoform 2b precursor
NM_001270605.1 NP_001257534.1 glutamate receptor ionotropic, NMDA 1 isoform 2a precursor
NM_001270606.1 NP_001257535.1 glutamate receptor ionotropic, NMDA 1 isoform 3b precursor
NM_001270608.1 NP_001257537.1 glutamate receptor ionotropic, NMDA 1 isoform 4b precursor
NM_001270610.1 NP_001257539.1 glutamate receptor ionotropic, NMDA 1 isoform 4a precursor
NM_001287423.1 NP_001274352.1 glutamate receptor ionotropic, NMDA 1 isoform 3a precursor
NM_017010.2 NP_058706.1 glutamate receptor ionotropic, NMDA 1 isoform 1a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NMDA glutamate receptor activity IDA
IDA: Inferred from direct assay
1350383 RGD
enables NMDA glutamate receptor activity IGI
IGI: Inferred from genetic interaction
7929101 RGD
enables NMDA glutamate receptor activity IMP
IMP: Inferred from mutant phenotype
17050728 RGD
enables amyloid-beta binding IDA
IDA: Inferred from direct assay
17308309 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
15069201 RGD
enables glutamate binding IDA
IDA: Inferred from direct assay
8011339 RGD
enables glutamate receptor binding IPI
IPI: Inferred from physical interaction
11239437 RGD
enables glutamate-gated receptor activity IDA
IDA: Inferred from direct assay
16477151 RGD
enables glycine binding IDA
IDA: Inferred from direct assay
8011339 RGD
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
10414981 RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential EXP
EXP: Inferred from Experiment
19666514 RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
19666514 RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
19666514 RGD
enables phosphatase binding IDA
IDA: Inferred from direct assay
15102920 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8780649 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
21544205 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17308309 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
12408866 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
12160751 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
12160751 RGD
enables voltage-gated monoatomic cation channel activity IMP
IMP: Inferred from mutant phenotype
17050728 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
1350383 RGD
involved in cellular response to glycine IEP
IEP: Inferred from expression pattern
23678131 RGD
involved in cellular response to manganese ion IEP
IEP: Inferred from expression pattern
19643132 RGD
involved in ionotropic glutamate receptor signaling pathway IDA
IDA: Inferred from direct assay
16477151 RGD
involved in monoatomic cation transmembrane transport IDA
IDA: Inferred from direct assay
22246434 RGD
involved in positive regulation of Schwann cell migration IMP
IMP: Inferred from mutant phenotype
26656067 RGD
involved in positive regulation of calcium ion transport into cytosol IGI
IGI: Inferred from genetic interaction
17308309 RGD
involved in positive regulation of dendritic spine maintenance IGI
IGI: Inferred from genetic interaction
17360908 RGD
involved in positive regulation of excitatory postsynaptic potential IDA
IDA: Inferred from direct assay
12930820 RGD
involved in positive regulation of reactive oxygen species biosynthetic process IGI
IGI: Inferred from genetic interaction
17308309 RGD
involved in positive regulation of synaptic transmission, glutamatergic IDA
IDA: Inferred from direct assay
19793963 RGD
involved in protein heterotetramerization IDA
IDA: Inferred from direct assay
24876489 RGD
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
22493736 RGD
involved in regulation of monoatomic cation transmembrane transport IDA
IDA: Inferred from direct assay
19793963 RGD
involved in response to amine IEP
IEP: Inferred from expression pattern
19918184 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
19761817 RGD
involved in response to fungicide IEP
IEP: Inferred from expression pattern
19591855 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
18927268 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19322657 RGD
involved in rhythmic process IDA
IDA: Inferred from direct assay
16477151 RGD
Cellular Component GO Annotation Evidence References Source
part of NMDA selective glutamate receptor complex IDA
IDA: Inferred from direct assay
16477151 RGD
located in cell surface IDA
IDA: Inferred from direct assay
17526495 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
16477151 RGD
located in dendrite membrane IDA
IDA: Inferred from direct assay
15620359 RGD
located in dendritic branch IDA
IDA: Inferred from direct assay
10618500 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
17207780 RGD
located in excitatory synapse IDA
IDA: Inferred from direct assay
19730411 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
12160751 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
12160751 RGD
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
23159309 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
10618500 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
19666514 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
1350383 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
23159309 RGD
located in postsynaptic density membrane IDA
IDA: Inferred from direct assay
26041915 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
23159309 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
19666514 RGD
located in synapse IDA
IDA: Inferred from direct assay
15681343 RGD
located in synaptic cleft IDA
IDA: Inferred from direct assay
17207780 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
10414981 RGD
located in synaptic membrane IPI
IPI: Inferred from physical interaction
17308309 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
19666514 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate receptor ionotropic, NMDA 1

  • N-methyl-D-aspartate glutamate receptor

  • N-methyl-D-aspartate receptor subunit NR1

  • NMD-R1

  • NMDA R1 receptor C1 cassette

  • glutamate [NMDA] receptor subunit zeta-1

  • glutamate receptor, ionotropic, N-methyl D-aspartate 1

  • neurotransmitter receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05803 GRIN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05754 GPRIN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20948 Grin1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27465 Grin1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grin1 NCBI NCBI:2902