Grm2 - glutamate metabotropic receptor 2 Gene

Rattus norvegicus

Gene ID: 24415 | Gene type: protein coding

About Grm2

Primary_assembly 8: 107,280,099-107,293,146 reverse strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 280 orthologues, 7 paralogues and is associated with 23 phenotypes. Restricted expression toward (RPKM 34.5).

Summary

Enables group II metabotropic glutamate receptor activity and scaffold protein binding activity. Involved in several processes, including behavioral response to nicotine; glutamate secretion; and regulation of amine transport. Acts upstream of or within regulation of protein kinase B signaling. Located in astrocyte projection; axon; and presynaptic membrane. Is integral component of postsynaptic membrane. Used to study heroin dependence. Orthologous to human GRM2 (glutamate metabotropic receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Grm2 Products(1)

mRNA	Protein	Name
NM_001105711.1	NP_001099181.1	metabotropic glutamate receptor 2 precursor

Grm2 Protein Structure

PBP1_mGluR_groupII

NCD3G

7tmC_mGluR2

0
200
400
600
800
872 a.a.

Protein Preferred Names

Protein Names

metabotropic glutamate receptor 2

glutamate receptor, metabotropic 2

mGluR2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS05822	GRM2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS05823	Grm2 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS05824	Grm2 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grm2	NCBI	NCBI:2912

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