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Grm2 - glutamate metabotropic receptor 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24415

About Grm2

Primary_assembly 8: 107,280,099-107,293,146 reverse strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 280 orthologues, 7 paralogues and is associated with 23 phenotypes. Restricted expression toward (RPKM 34.5).

Summary

Enables group II metabotropic glutamate receptor activity and scaffold protein binding activity. Involved in several processes, including behavioral response to nicotine; glutamate secretion; and regulation of amine transport. Acts upstream of or within regulation of protein kinase B signaling. Located in astrocyte projection; axon; and presynaptic membrane. Is integral component of postsynaptic membrane. Used to study heroin dependence. Orthologous to human GRM2 (glutamate metabotropic receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Grm2 Products (1)

mRNA	Protein	Name
NM_001105711.1	NP_001099181.1	metabotropic glutamate receptor 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables group II metabotropic glutamate receptor activity	IMP IMP: Inferred from mutant phenotype	12837619	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18555800	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	28392297	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in behavioral response to nicotine	IMP IMP: Inferred from mutant phenotype	28700935	RGD
involved in glutamate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28392297	RGD
involved in glutamate secretion	IDA IDA: Inferred from direct assay	15993439	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	28392297	RGD
involved in regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	30283001	RGD
involved in regulation of glutamate secretion	IMP IMP: Inferred from mutant phenotype	28700935	RGD
involved in regulation of response to drug	IMP IMP: Inferred from mutant phenotype	28700935	RGD
involved in response to cocaine	IMP IMP: Inferred from mutant phenotype	28700935	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in astrocyte projection	IDA IDA: Inferred from direct assay	28392297	RGD
located in axon	IDA IDA: Inferred from direct assay	15993439	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	35511883	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	15993439	RGD
is active in presynaptic membrane	IMP IMP: Inferred from mutant phenotype	35511883	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm2 Protein Structure

PBP1_mGluR_groupII

NCD3G

7tmC_mGluR2

0
200
400
600
800
872 a.a.

Protein Preferred Names	Protein Names
metabotropic glutamate receptor 2	glutamate receptor, metabotropic 2 mGluR2

Grm2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Grm2	P31421	RANBP9	Homo sapiens	Q96S59	Pull Down	18555800
Cross	Grm2	P31421	RANBP9	Homo sapiens	Q96S59	Y2H	18555800
Intra	Grm2	P31421	Htr2a	Rattus norvegicus	P14842	Anti Tag CoIP	19590495
Intra	Grm2	P31421	Htr2a	Rattus norvegicus	P14842	FRET	19590495

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05822	GRM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05823	Grm2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05824	Grm2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grm2	NCBI	NCBI:2912