Grm4 - glutamate metabotropic receptor 4 Gene

Also Known as mGluR4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24417

About Grm4

Primary_assembly 20: 5,481,124-5,572,821 reverse strand.mRatBN7.2:CM026993.1

This gene has 4 transcripts (splice variants), 271 orthologues, 7 paralogues and is associated with 3 phenotypes. Restricted expression toward (RPKM 46.3).

Summary

Enables calcium-dependent protein binding activity and Calmodulin binding activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; modulation of chemical synaptic transmission; and positive regulation of MAPK cascade. Predicted to act upstream of or within chemical synaptic transmission and learning. Located in dendritic shaft; presynaptic active zone membrane; and terminal bouton. Orthologous to human GRM4 (glutamate metabotropic receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Grm4 Products (1)

mRNA Protein Name
NM_022666.2 NP_073157.2 metabotropic glutamate receptor 4 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
21855531 RGD
enables calmodulin binding IPI
IPI: Inferred from physical interaction
21855531 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19822743 RGD
Cellular Component GO Annotation Evidence References Source
located in dendritic shaft IDA
IDA: Inferred from direct assay
11906782 RGD
located in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
11906782 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
11906782 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm4 Protein Structure

PBP1_mGluR_groupIII

PBP1_mGluR_groupIII: cd06376 (42 - 507)

NCD3G

NCD3G: pfam07562 (515 - 565)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (585 - 911)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (585 - 610)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (622 - 643)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (652 - 676)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (698 - 718)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (748 - 774)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (782 - 805)

7tmC_mGluR4

7tmC_mGluR4: cd15452 (815 - 840)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 912 a.a.
Protein Preferred Names Protein Names

metabotropic glutamate receptor 4

  • glutamate receptor, metabotropic 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15476 VU 0364439 99.42% Unkown
HY-RS05828 GRM4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05829 Grm4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05830 Grm4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grm4 NCBI NCBI:2914