Gstm2 - glutathione S-transferase mu 2 Gene

Also Known as GSTA4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24424

Summary

Enables glutathione binding activity; glutathione transferase activity; and identical protein binding activity. Involved in several processes, including glutathione metabolic process; response to phenylpropanoid; and xenobiotic catabolic process. Located in cytosol and plasma membrane. Part of protein-containing complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); and lung disease (multiple). Orthologous to several human genes including GSTM1 (Glutathione S-transferase mu 1). [provided by Alliance of Genome Resources, Apr 2022]

Gstm2 Products (1)

mRNA Protein Name
NM_177426.2 NP_803175.1 glutathione S-transferase Mu 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutathione binding IDA
IDA: Inferred from direct assay
17112229 RGD
enables glutathione transferase activity IDA
IDA: Inferred from direct assay
17112229 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
11015213 RGD
Biological Process GO Annotation Evidence References Source
involved in glutathione metabolic process IMP
IMP: Inferred from mutant phenotype
12027896 RGD
involved in response to catechin IEP
IEP: Inferred from expression pattern
10927022 RGD
involved in response to genistein IEP
IEP: Inferred from expression pattern
19451092 RGD
involved in response to metal ion IEP
IEP: Inferred from expression pattern
23470461 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
14646352 RGD
involved in xenobiotic catabolic process IDA
IDA: Inferred from direct assay
17112229 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
17112229 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
11015213 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutathione S-transferase Mu 2

  • GST 4-4

  • GST Yb2

  • GSTM2-2

  • Glutathione-S-transferase, mu type 2 (Yb2)

  • glutathione S-transferase M2

  • glutathione S-transferase Yb-2

  • glutathione S-transferase Yb2 subunit

Related Agents

  • Approval

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0122 Plicamycin Inhibitor 99.60% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gstm2 NCBI NCBI:2946