Hrh1 - histamine receptor H 1 Gene

Also Known as Hisr

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24448

About Hrh1

Primary_assembly 4: 147,645,995-147,647,455 forward strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 186 orthologues, 35 paralogues and is associated with 12 phenotypes.

Summary

Enables histamine binding activity. Involved in several processes, including negative regulation of steroid biosynthetic process; positive regulation of nitric oxide biosynthetic process; and positive regulation of vasoconstriction. Predicted to be located in cytosol and plasma membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Orthologous to human HRH1 (Histamine Receptor H1). [provided by Alliance of Genome Resources, Apr 2022]

Hrh1 Products (1)

mRNA Protein Name
NM_017018.2 NP_058714.2 histamine H1 receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables histamine binding IMP
IMP: Inferred from mutant phenotype
7678492 RGD
Biological Process GO Annotation Evidence References Source
involved in chemical synaptic transmission IDA
IDA: Inferred from direct assay
12419527 RGD
involved in negative regulation of steroid biosynthetic process IMP
IMP: Inferred from mutant phenotype
15917347 RGD
involved in positive regulation of nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
12419527 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
17169617 RGD
involved in response to gravity IEP
IEP: Inferred from expression pattern
18607976 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hrh1 Protein Structure

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (84 - 533)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (84 - 110)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (117 - 143)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (155 - 185)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (197 - 218)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (242 - 271)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (462 - 492)

7tmA_Histamine_H1R

7tmA_Histamine_H1R: cd15050 (501 - 526)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 542 a.a.
Protein Preferred Names Protein Names

histamine H1 receptor

  • H1R

  • HH1R

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03753 DHX34 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03760 DHX8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06359 HRH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06360 Hrh1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06361 Hrh1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hrh1 NCBI NCBI:3269