Hspb1 - heat shock protein family B (small) member 1 Gene

Also Known as Hsp25; Hsp27

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24471

Summary

Enables ubiquitin binding activity. Involved in several processes, including cellular response to butyrate; cellular response to interleukin-11; and response to ischemia. Located in several cellular components, including myofibril; perikaryon; and postsynaptic density membrane. Part of Proteasome complex. Biomarker of Alzheimer's disease and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1). [provided by Alliance of Genome Resources, Apr 2022]

Hspb1 Products (1)

mRNA Protein Name
NM_031970.4 NP_114176.4 heat shock protein beta-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11546764 RGD
enables ubiquitin binding IDA
IDA: Inferred from direct assay
12897149 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to butyrate IEP
IEP: Inferred from expression pattern
11522747 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
16324708 RGD
involved in cellular response to interleukin-11 IEP
IEP: Inferred from expression pattern
12730876 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
21900647 RGD
involved in negative regulation of cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
11522747 RGD
involved in negative regulation of regulatory T cell differentiation IMP
IMP: Inferred from mutant phenotype
30287503 RGD
involved in positive regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
18541665 RGD
involved in response to angiotensin IEP
IEP: Inferred from expression pattern
21931298 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
10559386 RGD
involved in response to muscle stretch IEP
IEP: Inferred from expression pattern
21900647 RGD
Cellular Component GO Annotation Evidence References Source
located in I band IDA
IDA: Inferred from direct assay
9396443 RGD
located in M band IDA
IDA: Inferred from direct assay
9396443 RGD
located in axon IDA
IDA: Inferred from direct assay
22617993 RGD
located in cardiac myofibril IDA
IDA: Inferred from direct assay
9396443 RGD
located in dendrite IDA
IDA: Inferred from direct assay
22617993 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
22617993 RGD
located in postsynaptic density membrane IDA
IDA: Inferred from direct assay
22617993 RGD
part of proteasome complex IDA
IDA: Inferred from direct assay
12897149 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heat shock protein beta-1

  • HSP 27

  • heat shock 27 kDa protein 1

  • heat shock 27kDa protein 1

  • heat shock protein B1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06438 HSPB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24382 Hspb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17913 Hspb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hspb1 NCBI NCBI:3315