Lepr - leptin receptor Gene

Also Known as Fa

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24536

Summary

Enables peptide hormone binding activity and protein-hormone receptor activity. Involved in several processes, including gonad development; negative regulation of locomotor rhythm; and positive regulation of cell communication. Located in extracellular space and plasma membrane. Used to study several diseases, including chronic kidney disease; glucose metabolism disease (multiple); obesity; pancreatitis; and renal fibrosis. Biomarker of pre-eclampsia and short bowel syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (Leptin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Lepr Products (1)

mRNA Protein Name
NM_012596.2 NP_036728.2 leptin receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptide hormone binding IDA
IDA: Inferred from direct assay
9070213 RGD
enables peptide hormone binding IMP
IMP: Inferred from mutant phenotype
17023527 RGD
enables protein-hormone receptor activity IDA
IDA: Inferred from direct assay
9070213 RGD
enables protein-hormone receptor activity IMP
IMP: Inferred from mutant phenotype
17023527 RGD
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IMP
IMP: Inferred from mutant phenotype
12393625 RGD
involved in cellular response to acetate IEP
IEP: Inferred from expression pattern
12928006 RGD
involved in cellular response to butyrate IEP
IEP: Inferred from expression pattern
12928006 RGD
involved in eating behavior IMP
IMP: Inferred from mutant phenotype
12824696 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
12297537 RGD
involved in leptin-mediated signaling pathway IDA
IDA: Inferred from direct assay
9070213 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
11159367 RGD
involved in negative regulation of eating behavior IMP
IMP: Inferred from mutant phenotype
16982424 RGD
involved in negative regulation of locomotor rhythm IMP
IMP: Inferred from mutant phenotype
16982424 RGD
involved in ovulation from ovarian follicle IEP
IEP: Inferred from expression pattern
12959975 RGD
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
9618284 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
9751766 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
12297537 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
15059958 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
15284063 RGD
involved in response to leptin IEP
IEP: Inferred from expression pattern
18515494 RGD
involved in response to lipid IEP
IEP: Inferred from expression pattern
9751212 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
12576193 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
18755573 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
16037380 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leptin receptor

  • LEP-R

  • Leptin receptor (fatty)

  • OB receptor

  • OB-R

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990631 Mibavademab Inhibitor ≥99.0% Phase 3

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07594 LEPR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07595 LEPROT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17371 Lepr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23825 Lepr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lepr NCBI NCBI:3953