Nppa - natriuretic peptide A Gene

Also Known as ANF; ANP; CDD; Pnd; RATANF

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24602

Summary

Enables hormone activity. Involved in several processes, including cGMP biosynthetic process; cellular response to mechanical stimulus; and regulation of ion transport. Acts upstream of or within receptor guanylyl cyclase signaling pathway. Located in several cellular components, including brush border; mast cell granule; and perinuclear region of cytoplasm. Used to study congestive heart failure; pulmonary hypertension; and ureteral obstruction. Biomarker of acute kidney failure; artery disease (multiple); hypertrophic cardiomyopathy; and nephrosis. Human ortholog(s) of this gene implicated in artery disease (multiple); heart conduction disease (multiple); and peritonitis. Orthologous to human NPPA (natriuretic peptide A). [provided by Alliance of Genome Resources, Apr 2022]

Nppa Products (1)

mRNA Protein Name
NM_012612.2 NP_036744.1 natriuretic peptides A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hormone activity IDA
IDA: Inferred from direct assay
7552344 RGD
enables signaling receptor binding IDA
IDA: Inferred from direct assay
11751587 RGD
Biological Process GO Annotation Evidence References Source
involved in cGMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
10559136 RGD
involved in cGMP-mediated signaling IDA
IDA: Inferred from direct assay
12217425 RGD
involved in cell growth involved in cardiac muscle cell development IEP
IEP: Inferred from expression pattern
7657802 RGD
involved in cellular response to angiotensin IEP
IEP: Inferred from expression pattern
27249171 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
27249171 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
23617620 RGD
involved in negative regulation of cell growth IMP
IMP: Inferred from mutant phenotype
16010968 RGD
involved in negative regulation of collecting lymphatic vessel constriction IDA
IDA: Inferred from direct assay
23897233 RGD
involved in negative regulation of systemic arterial blood pressure IDA
IDA: Inferred from direct assay
2136863 RGD
involved in positive regulation of cGMP-mediated signaling IDA
IDA: Inferred from direct assay
7552344 RGD
involved in positive regulation of delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
8301666 RGD
involved in positive regulation of histamine secretion by mast cell IDA
IDA: Inferred from direct assay
9663691 RGD
involved in positive regulation of potassium ion export across plasma membrane IDA
IDA: Inferred from direct assay
8301666 RGD
acts upstream of or within receptor guanylyl cyclase signaling pathway IDA
IDA: Inferred from direct assay
17951249 RGD
involved in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IDA
IDA: Inferred from direct assay
8301666 RGD
involved in regulation of high voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
8301666 RGD
involved in response to 3-methylcholanthrene IEP
IEP: Inferred from expression pattern
19889059 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
2136863 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
16828931 RGD
involved in synaptic signaling via neuropeptide EXP
EXP: Inferred from Experiment
24060848 RGD
involved in synaptic signaling via neuropeptide IDA
IDA: Inferred from direct assay
24060848 RGD
involved in synaptic signaling via neuropeptide IMP
IMP: Inferred from mutant phenotype
24060848 RGD
Cellular Component GO Annotation Evidence References Source
located in brush border IDA
IDA: Inferred from direct assay
1372667 RGD
is active in glycinergic synapse EXP
EXP: Inferred from Experiment
24060848 RGD
is active in glycinergic synapse IDA
IDA: Inferred from direct assay
24060848 RGD
is active in glycinergic synapse IMP
IMP: Inferred from mutant phenotype
24060848 RGD
located in mast cell granule IDA
IDA: Inferred from direct assay
16246270 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16270351 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

natriuretic peptides A

  • Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd)

  • atrial natriuretic factor prohormone

  • atrial natriuretic peptide prohormone

  • atriopeptigen

  • cardiodilatin

  • natriuretic peptide precursor type A

  • preproANF

  • preproANP

  • preproCDD-ANF

  • prepro

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99047 Simtuzumab Inhibitor ≥99.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09494 NPPA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180583 GRK5-IN-5 Inhibitor / Unkown
HY-RS19624 Nppa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26119 Nppa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nppa NCBI NCBI:4878
Canis familiaris Nppa NCBI NCBI:608289
Macaca fascicularis Nppa NCBI NCBI:102116318
Mus musculus Nppa NCBI NCBI:230899