PLA2G4A - Pla2g4a phospholipase A2 group IVA Gene

Also Known as Pla2c; cPLA2; Pla2g4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24653

Summary

Enables calcium-dependent Phospholipase A2 activity and Histone Acetyltransferase binding activity. Involved in several processes, including positive regulation of prostaglandin biosynthetic process; reproductive structure development; and surfactant homeostasis. Located in several cellular components, including cytosol; perinuclear region of cytoplasm; and zymogen granule. Used to study hyperglycemia. Biomarker of asthma; brain ischemia; papilloma; polycystic kidney disease; and transitional cell carcinoma. Orthologous to human PLA2G4A (Phospholipase A2 group IVA). [provided by Alliance of Genome Resources, Apr 2022]

PLA2G4A Products (1)

mRNA Protein Name
NM_133551.2 NP_598235.2 cytosolic phospholipase A2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent phospholipase A2 activity IDA
IDA: Inferred from direct assay
8148815 RGD
enables histone acetyltransferase binding IPI
IPI: Inferred from physical interaction
11416127 RGD
Biological Process GO Annotation Evidence References Source
involved in arachidonate metabolic process IMP
IMP: Inferred from mutant phenotype
16603549 RGD
involved in cellular response to homocysteine IEP
IEP: Inferred from expression pattern
31125437 RGD
involved in decidualization IMP
IMP: Inferred from mutant phenotype
10050766 RGD
involved in luteolysis IEP
IEP: Inferred from expression pattern
11444430 RGD
involved in ovulation from ovarian follicle IMP
IMP: Inferred from mutant phenotype
10189070 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15486059 RGD
involved in positive regulation of bone mineralization IEP
IEP: Inferred from expression pattern
10807497 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17060404 RGD
involved in positive regulation of fever generation IEP
IEP: Inferred from expression pattern
16933973 RGD
involved in positive regulation of prostaglandin biosynthetic process IMP
IMP: Inferred from mutant phenotype
16203828 RGD
involved in positive regulation of vesicle fusion IMP
IMP: Inferred from mutant phenotype
17148545 RGD
involved in response to calcium ion IMP
IMP: Inferred from mutant phenotype
16828086 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
10092307 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
15368358 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
16864412 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17093905 RGD
involved in response to methylmercury IEP
IEP: Inferred from expression pattern
15019302 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
15225789 RGD
involved in surfactant homeostasis IMP
IMP: Inferred from mutant phenotype
10025671 RGD
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15486059 RGD
located in zymogen granule IDA
IDA: Inferred from direct assay
17148545 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytosolic phospholipase A2

  • cytosolic phospholipase A2-like

  • phospholipase A2 cytosolic

  • phospholipase A2, group IVA (cytosolic, calcium-dependent)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18540 KT109 Inhibitor 99.86% Unkown
HY-RS10626 PLA2G4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17434 Pla2g4a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23889 Pla2g4a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PLA2G4A NCBI NCBI:5321